The idea of hierarchy, widely observed in natural and artificial worlds, has been extensively explored in chemistry and materials science. Similar to proteins which contain primary, secondary, tertiary and quaternary structures, the varying levels of hierarchy in metal-organic framework (MOF) superstructures can also be achieved. In this work, we initiate a systematic study on the morphological evolution

DNA-Nanoparticle conjugates have found widespread use in sensing, imaging, and as components of devices. However, their synthesis remains relatively complicated and empirically based, often requiring specialized protocols for conjugates of different size, valence, and elemental composition. Here we report a novel, bottom-up approach for the synthesis of nanoparticle-DNA conjugates, based on ring-opening

Single atom catalysts receive considerable attention due to reducing noble metal utilization and potentially eliminating certain side reactions. Yet, the rational design of highly reactive and stable single atom catalysts is hampered by the current lack of fundamental insights at the single atom limit. Here, density functional theory calculations are performed for a prototype reaction, namely CO oxidation

We demonstrate a simple method for real-time monitoring of mechanochemical synthesis of metal-organic frameworks, by measuring changes in pressure of gas produced in the reaction. Using this manometric method to monitor the mechanosynthesis of the zeolitic imidazolate framework ZIF-8 from basic zinc carbonate reveals an intriguing feedback mechanism in which the initially formed ZIF-8 reacts with the

We report an approach to rotaxanes in which the metal ion of a cyclometallated PtII luminophore is embedded in the space created by the mechanical bond. Our results show that the interlocked ligand environment stabilises a normally labile PtII-triazole bond against displacement by competing ligands and that the crowded environment of the mechanical bond retards oxidation of the PtII centre, without

Given the powerful regulation roles of chemical modification networks on protein structures and functions, it is of vital importance to acquire the spatiotemporal chemical modification pattern information in a protein-specific fashion, which is by far a highly challenging task. Herein, we design a localized DNA automaton, equipped with an anticoding-coding sequential propagation algorithm, for in situ

Increased molecular complexity correlates with improved chances of success in the drug development process. Here, a strategy for the creation of sp3-rich, non-planar heterocyclic scaffolds suitable for drug discovery is described that obviates the need to generate multiple stereogenic centers with independent control. Asymmetric transfer hydrogenation using a tethered Ru-catalyst is used to efficiently

Alkyl-substituted carbene (CHR or CR2, R = alkyl) complexes have been extensively studied for alkylcarbene (CHR) ligands coordinated with high-valent early transition metal ions (a.k.a. Schrock carbenes or alkylidenes), yet dialkylcarbene (CR2) complexes remain less developed with bis(dialkylcarbene) species being little (if any) explored. Herein, several group 8 metal porphyrin dialkylcarbene complexes