ImportanceNearly 100 000 children experience physical abuse each year in the US. Among approximately 2000 annual deaths related to child maltreatment, more than 40% resulted from physical abuse, and half of those children were younger than 1 year. Many of these young children had unidentified abusive injuries before the fatal event.ObjectiveTo determine the accuracy of clinical and radiologic findings

This Viewpoint offers an account of the events surrounding the discovery of the biological action of glucagon-like peptide-1 and the roles of the individuals who contributed to the discovery.

High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer, accounting for approximately 70% of all ovarian cancer cases and contributing significantly to the high mortality rates associated with this disease. Because of the asymptomatic nature of early stage disease, most patients are diagnosed at advanced stages when the cancer has already spread into the

Prevention research aims to understand, mitigate and ultimately avert the onset and progression of disease and the spillover of pathogens. Such research includes the analysis of risk factors and fundamental mechanisms of disease emergence, early detection and screening, stratification into risk groups, and the development and evaluation of preventive interventions. In the face of population aging and

CD19 chimeric antigen receptor (CD19-CAR) T-cell therapy has been shown to induce stable drug-free remission in patients with refractory autoimmune disease. The management of potential relapses is currently unclear. Here, we report on a 45-year-old woman with treatment-refractory Jo-1-associated anti-synthetase syndrome, who initially achieved disease remission after CD19-CAR T-cell therapy but then

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This Medical News article is an interview with Arthur Brant, MD, and Sunny Virmani, MS, about their recent research on AI screening for diabetic retinopathy in large-scale clinical settings in India.

This Medical News article discusses recent landmark work to visualize the structure of the cholesterol-carrying low-density lipoprotein (LDL) particle bound to its cell surface receptor.

This Medical News article discusses how recent workforce and program reductions at the US Centers for Disease Control and Prevention will affect public health.

An AI-driven screener for opioid use disorder in hospital settings could increase referrals to addiction services and improve patient outcomes, but it is crucial that treatment is accessible and that unintended harms such as stigma are avoided.

Despite a negative primary outcome, a trial of gantenerumab showed a clinically meaningful slowing of disease onset in asymptomatic people who were treated for the longest duration.

Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03589-8, published online 1 April 2025.

Objective To take advantage of the arbitrarily timed increase in firearm and ammunition availability brought on by the start of deer hunting seasons to study its impact on hunting, and importantly, non-hunting related firearm incidents. Design Quasi-experimental analysis using start of hunting season in United States. Setting Populations of US states with highest number of hunting accidents reported

### What you need to know ### BMJ Learning To obtain accredited continuous professional development points, complete the full BMJ Learning module at https://new-learning.bmj.com/course/10064619. The module contains eight additional questions submitted by users of BMJ Learning, including therapeutic cooling, posterior circulation stroke, stroke recovery, and mechanical thrombectomy. Stroke physician

Tom Nolan reviews this week’s research It wasn’t long ago that we’d routinely. advise people with heart failure and fluid overload to restrict their fluid intake. Nowadays, restriction advice is restricted to only a few, such as those with dilutional hyponatraemia. A new multicentre, open-label trial supports this approach. It randomised 504 people with chronic heart failure attending outpatient clinics

Central to the government's mission to improve health and fix the NHS is a “shift from sickness to prevention.”1 Yet key indicators suggest we are moving in the wrong direction. Healthy life expectancy is declining, obesity rates are rising, health inequalities are more pronounced than ever, and economic inactivity due to ill health is at an all time high.2345 Tobacco, alcohol, and unhealthy food are

The summaries of product characteristics (SmPCs; previously called data sheets) of certain drugs sometimes specify that they should be used “at the discretion of the physician,” often when advising about use in special groups, such as pregnant women or children. My interpretation of this at first reading was, not simply that the advice was required, but that a physician was specifically required to

First developed in the 1960s, tranexamic acid, an inhibitor of plasminogen activation and fibrinolysis, found niche applications in treating hereditary bleeding disorders. The indications for drugs often narrow over time, but the uses of tranexamic acid have broadened. It’s now commonly used to prevent blood loss in a variety of clinical conditions. The results of a recent trial suggest it should be

A woman in her early 60s presented with a three day history of a widespread, itchy rash. She had no relevant history and was not on any regular medications, but the rash occurred after she had worn new clothing. Examination showed symmetrical erythema, …

Many high risk, high reward medical therapies that use cutting edge science are proving themselves in clinical trials. But are health services ready to pay for them—and how? Marianne Guenot reports On 16 September 2024 Jimi Olaghere became the first person with sickle cell disease to reach the summit of Mount Kilimanjaro. The 39 year old could hardly believe it as he contemplated his achievement from

Role of artificial intelligence in identifying colorectal cancer is still evolving Colorectal cancer (CRC) is the third most common cancer worldwide, often arising from precancerous adenomas.12 Therefore, adenoma detection rate (ADR) is a key quality measure for colonoscopy, with higher ADRs associated with an improved survival benefit.34 Given the importance of this metric, advancements in artificial

The UK population’s health is getting worse. Health inequalities are widening and obesity rates rising, particularly among children in deprived areas (doi:10.1136/bmj.q2819 doi:10.1136/bmj.r525 doi:10.1136/bmj.q2457 doi:10.1136/bmj.r593).1234 A new investigation by The BMJ explores the influence of industry on some of these trends (doi:10.1136/bmj.r667).5 The investigation finds that the advertising

Prolonged grief disorder is a mental health disorder recently included in diagnostic manuals worldwide. This Review presents published research evidence in strong support for the current conceptualisation of prolonged grief disorder: a diagnosable mental health condition with core symptoms of yearning, preoccupation, or both, which is associated with symptoms of emotional pain, identity disturbances

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Section snippetsAn unwelcoming realityThose who survive detention are faced with a harsh reality once outside. Many return to heavily damaged or destroyed neighbourhoods, have financial problems, and are unable to find work in Syria's devasted economy. Family members who awaited the return of their loved ones for years might expect men or sons to retake their role as breadwinners, although they often

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BACKGROUND Tecovirimat is available for the treatment of mpox (formerly known as monkeypox) in Europe and the United States, on the basis of findings from efficacy studies in animals and safety evaluations in healthy humans. Evidence from randomized, controlled trials of safety and efficacy in patients with mpox is lacking. METHODS We conducted a double-blind, randomized, placebo-controlled trial

BACKGROUND Treatment with fidanacogene elaparvovec, a recombinant adeno-associated virus (AAV) vector developed for the treatment of hemophilia B, led to sustained expression of the high-activity factor IX variant (FIX-R338L, or FIX-Padua) in a phase 1-2a study. The long-term safety and efficacy of this treatment are not known. METHODS In a 12-month study, 15 participants with severe or moderately

This study compares the prevalence of obesity (assessed by body mass index only) vs obesity prevalence when excess adiposity is confirmed by waist circumference measurement or dual-energy x-ray absorptiometry in a nationally representative sample of US adults.

In this narrative medicine essay, a palliative care pediatrician ponders the question of whether she would pick the same career in light of the challenges of practicing medicine and garnering respect for her subspecialty.

This Viewpoint discusses how psychiatry can benefit from a public commission that promulgates a reform agenda focused on improving access to care, reducing stigma, and conducting research on topics that patients and the public care about.