Independent Control over Size, Valence, and Elemental Composition in the Synthesis of DNA-Nanoparticle Conjugates,Chemical Science

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Independent Control over Size, Valence, and Elemental Composition in the Synthesis of DNA-Nanoparticle Conjugates
Chemical Science ( IF 9.969 ) Pub Date : 2023-02-15 , DOI: 10.1039/c9sc05656d
Yugang Bai, Hang Xing, Yunhao Bai, Li Huey Tan, Kevin Hwang, Ji Li, Yi Lu, Steven C. Zimmerman

DNA-Nanoparticle conjugates have found widespread use in sensing, imaging, and as components of devices. However, their synthesis remains relatively complicated and empirically based, often requiring specialized protocols for conjugates of different size, valence, and elemental composition. Here we report a novel, bottom-up approach for the synthesis of nanoparticle-DNA conjugates, based on ring-opening metathesis polymerization (ROMP), intramolecular crosslinking and template synthesis. Using size, valence, and elemental composition as three independent synthetic parameters, various conjugates can be obtained using a facile and universal procedure. Examples are given to show the usefulness of these conjugates as sensing probes, building blocks for self-assembly, and structure-property relationship studies.

更新日期：2020-01-04

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