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成果及论文

Publications (corresponding/first author papers only)0

  1. Kong C; Li Y; Liu Z; Ye J; Wang Z; Zhang L; Kong W.; Liu H.; Liu C.; Pang H.; Hu Z.; Gao J.; and Qian, F*, Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release, ACS Nano, DOI: 10.1021/acsnano.8b08246, Publication Date (Web): March 26, 2019
  3. Chen H.; Zhang X.; Cheng Y.; Qian,F*, Preparation of smectic itraconazole nanoparticles with tunable periodic order using microfluidics based anti-solvent precipitation, CrystEngComm, 2019, 21,
  4. Liu H; Sun M; Liu Z; Kong C; Kong W; Ye J; Gong J; Huang D; Qian, F.*, KRAS-enhanced macropinocytosis and reduced FcRn-mediated recycling sensitize pancreatic cancer to albumin-conjugated drugs, Journal of Controlled Release, Vol 296, 28 February 2019, Pages 40-53 
  5. Liu C; Xu C; Yu J; Pui Y; Chen H; Wang S; Zhu A; Li J; Qian F.*, Impact of a Single Hydrogen Substitution by Fluorine on the Molecular Interaction and Miscibility between Sorafenib and Polymers, Mol. Pharmaceutics, 2019, 16 (1), pp 318–326
  6. Chen, Y.; Pui, Y.; Chen, H.; Wang, S; Serno, P.; Tonnis, W.; Chen, L.; Qian F.*, Polymer mediated drug supersaturation controlled by drug-polymer interactions persisting in aqueous environment, 19 Nov 2018, Mol. Pharmaceutics, 2019, 16 (1), pp 205–213 
  7. Zhang L, Liu Z, Kong C, Liu C, Yang K, Chen H, Huang J, Qian F*., Improving Drug Delivery of Micellar Paclitaxel against Non‐Small Cell Lung Cancer by Coloading Itraconazole as a Micelle Stabilizer and a Tumor Vascular Manipulator, Small, 16 November 2018 https://doi.org/10.1002/smll.201802112
  8. Liu L.; Kong C.; Huo M.; Liu C.; Peng L.; Zhao T.; Wei Y.; Qian F*, Yuan J.*; Schiff base interaction tuned mesoporous organosilica nanoplatforms with pH-responsive degradability for efficient anti-cancer drug delivery in vivo, Chem. Commun., 2018, 54, 9190-9193
  9. Wang S,; Liu C,; Chen Y.; Zhu A.; Qian F*, Aggregation of Hydroxypropyl Methylcellulose Acetate Succinate under Its Dissolving pH and the Impact on Drug Supersaturation, Mol. Pharmaceutics, 2018, 15, 4643−4653
  10. Pui Y.; Chen Y.; Chen H.; Wang S.; Liu C.; Tonnis W.; Chen L.; Serno P.; Bracht S.; Qian F., Maintaining Supersaturation of Nimodipine by PVP with or without the Presence of Sodium Lauryl Sulfate and Sodium Taurocholate, Mol. Pharmaceutics, 2018, 15 (7), pp 2754–2763
  11. Chen Z., Yang K., Huang C., Zhu A., Yu L., Qian F.*, Surface Enrichment and Depletion of the Active Ingredient in Spray Dried Amorphous Solid Dispersions, Pharmaceutical Research (2018) 35: 38. https://doi.org/10.1007/s11095-018-2345-1
  12. Wang S.; Liu C.; Chen Y.; Zhang Z.; Zhub A.; Qian F.*; A high-sensitivity HPLC-ELSD method for HPMC-AS quantification and its application in elucidating the release mechanism of HPMC-AS based amorphous solid dispersions, Euro. J. Pharm. Sci. Vol. 122, 15 September 2018, Pages 303-310
  13. Chen H, Pui Y, Liu C, Chen Z, Su C, Hageman M, Hussain M, Haskell R, Stefanski K, Foster K, Gudmundsson O, Qian, F*, Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance, J Pharm Sci., January 2018, Volume 107, Issue 1, Pages 317–326
  14. Liu C.; Liu Z.; Chen Y.; Chen Z.; Chen H.; Pui Y.; Qian F.*, Oral bioavailability enhancement of β-lapachone, a poorly soluble fast crystallizer, by cocrystal, amorphous solid dispersion, and crystalline solid dispersion, Euro. J. Pharm. Biopharm, Vol. 124, March 2018, Pages 73-81, https://doi.org/10.1016/j.ejpb.2017.12.016
  15. Zhang X., Chen H., Qian F.*;  Cheng Y., Preparation of itraconazole nanoparticles by anti-solvent precipitation method using a cascaded microfluidic device and an ultrasonic spray drier, Chemical Engineering Journal, 334 (2018) 2264-2272
  16. Zhang L, Liu Z, Yang K, Kong C, Liu C, Chen H, Huang J, Qian F*. Tumor Progression of Non-Small Cell Lung Cancer Controlled by Albumin and Micellar Nanoparticles of Itraconazole, a Multitarget Angiogenesis Inhibitor, Mol Pharmaceutics. 2017, 14 (12), pp 4705–4713
  17. Zhang L, Sun H, Chen Z, Liu Z, Huang N, Qian F.*; Intermolecular Interactions between Coencapsulated Drugs Inhibit Drug Crystallization and Enhance Colloidal Stability of Polymeric Micelles. Mol Pharmaceutics. 2017, 14, 3568−3576 
  18. Wang S, Zhang X, Wu G, Tian Z, Qian F.*; Optimization of high-concentration endostatin formulation: Harmonization of excipients' contributions on colloidal and conformational stabilities.,  Int J Pharm. 2017 Sep 15;530(1-2):173-186. doi: 10.1016/j.ijpharm.2017.07.057. Epub 2017 Jul 26.
  19. Wu G, Wang Co-First S, Tian Z, Zhang N, Sheng H, Dai W, Qian F.*, Elucidating the Weak Protein-Protein Interaction Mechanisms behind the Liquid-Liquid Phase Separation of a mAb Solution by Different Types of Additives. Eur J Pharm Biopharm. 2017 Jul 25. pii: S0939-6411(17)30571-4. doi: 10.1016/j.ejpb.2017.07.012.
  20. Wang, S.; Wu, G.; Zhang, X.; Tian, Z.; Zhang, N.; Hu, T.; Dai.; W.; Qian F*, Stabilizing two IgG1 monoclonal antibodies by surfactants: Balance between aggregation prevention and structure perturbation, Euro. J. Pharm. Biopharm., Volume 114, May 2017, Pages 263–277
  21. Chen, Z.; Liu, CY.; Zhang, L.; Qian, F.*; Dissolution Characteristics of Fast-Crystallizing β-Lapachone within Different Semicrystalline Microstructures of Polyethylene Glycol or Poly(ethylene oxide)–Poly(propylene oxide)–Poly(ethylene oxide) Triblock Copolymer, Cryst. Growth Des., 2016, 16, 5367-5376
  22. Chen YJ.; Wang S; Wang S.; Liu C.; Su, C.; Hageman, M.; Hussain, M.; Haskell. R.; Stefanski K.;  Qian, F*.; Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMC-AS Amorphous Solid Dispersion, Mol. Pharmaceutics, 2016, 13, 2787-2795
  23. Chen YJ.; Wang S; Wang S.; Liu C.; Su, C.; Hageman, M.; Hussain, M.; Haskell. R.; Stefanski K.;  Qian, F*.; Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and Drug-Polymer Interaction, Pharmaceutical Research, 2016, 33(10), 2445-2458.
  24. Liu C, Chen Z, ChenYJ.; Lu J’; Li Y.; Wang S.; Wu G.; Qian F* Improving Oral Bioavailability of Sorafenib by Optimizing the “Spring” and “Parachute” Based on Molecular Interaction Mechanisms, Mol. Pharmaceutic, 2016, 13 (2), pp 599–608
  25. Wang S, Zhang N, Hu T, Dai W, Feng X, Zhang X, and Qian F*.; Viscosity-Lowering Effect of Amino Acids and Salts on Highly Concentrated Solutions of Two IgG1 Monoclonal Antibodies, Mol. Pharmaceutics, 2015, 12 (12), pp 4478–4487
  26. Zhang L, Zhen Chen, Kuan Yang, Chun Liu, Jinming Gao, and Qian, F*.; β-Lapachone and Paclitaxel Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy, Mol.Pharmaceutics, 2015, 12 (11), pp 3999–4010
  27. Liu C, Kong C, Wu G, Zhu J, Javid B, Qian F*, Uniform and amorphous rifampicin microspheres obtained by freezing induced LLPS during lyophilization, Int. J. Pharm., Volume 495, Issue 1, 10 November 2015, Pages 500–507
  28. Wang S, Liu H, Zhang X, Qian F*, Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies, Protein & Cell, July 2015, Volume 6, Issue 7, pp 480-503
  29. Chen, Z.; Liu,ZS.; Qian, F.*; Crystallization of Bifonazole and Acetaminophen within the Matrix of Semicrystalline, PEO-PPO-PEO Triblock Copolymers, Mol. Pharmaceutics, 2015 Feb 21;12(2):590-9.
  30. Chen YJ.; Liu CY.; Chen.Z.; Su, C.; Hageman, M.; Hussain, M.; Haskell. R.; Stefanski K.; Qian, F*.; Drug-polymer-water Interaction and its Implication to the Dissolution Performance of Amorphous Solid Dispersions, Mol. Pharmaceutics, 2015 Feb 12;12(2):576-89.
  31. Qian, F.*; Wang, J.; Hartley, R.; Tao, J.; Haddadin, R.; Mathias, N..; Hussain, M. Solution Behavior of PVP-VA and HPMC-AS Based Amorphous Solid Dispersions and Their Bioavailability Implications, Pharmaceutical Research, 2012, Oct 29 (10) 2765-76
  32. Qian, F.*; Huang, J.; Zhu, Q.; Haddadin, R.; Gawel, J.; Garmise, R.; Hussain, M. Is a Distinctive Single Tg a Reliable Indicator for the Homogeneity of Amorphous Solid Dispersion? International Journal of Pharmaceutics, Volume 395, Issues 1-2, 16 August 2010, Pages 232-235
  33. Qian, F.; Huang, J.; Hussain, M. Drug-polymer solubility and miscibility: stability consideration and practical challenges in amorphous solid dispersion development. Journal of Pharmaceutical Sciences, 2010, 99 (7), 2941-2947
  34. Qian, F.*; Ni, N.; Burton, L.; Wang, F.; Desikan, S.; Hussain, M.; Smith, RL. Sustained Release Subcutaneous Delivery of BMS-686117, a GLP-1 Receptor Agonist, Via Zinc Adduct.  International Journal of Pharmaceutics, Vol. 374, Issues 1-2, 5 June 2009, 46-52
  35. Qian, F.*; Moench, P.; Mathias, N.; Desikan, S.; Hussain, M.; Smith, RL. Pulmonary Delivery of a GLP-1 Receptor Agonist, BMS-686117.  International Journal of Pharmaceutics, Vol. 366, 2009, 218–220
  36. Qian, F.*; Ni, N.; Chen, JW.; Desikan, S.; Naringrekar, V.; Hussain, M.; Smith, RL. Formation of Zinc Peptide Spherical Microparticles during Lyophilization From tert-Butyl Alcohol/Water Co-solvent System.  Pharmaceutical Research, Vol. 25, No. 12, December 2008 
  37. Qian, F.*; Tao, J..; Desikan, S.; Hussain, M.; Smith, RL. Mechanistic Investigation of Pluronic® Based Nano-crystalline Solid Dispersion.  Pharmaceutical Research, 2007, 24(8):1551-60. 
  38. Qian, F.; Stowe, N.; Saidel G.; Gao, J.  Comparison of Doxorubicin Concentration Profiles in RF Ablated Rat Livers from Sustained and Dual-release PLGA Millirods.  Pharmaceutical Research. 2004, 21(3), 394-9.
  39. Qian, F.; Stowe, N.; Liu, E.H.; Saidel G.; Gao, J.  Quantification of In Vivo Doxorubicin Transport in Thermoablated Rat Livers from PLGA Millirods. Journal of Controlled Release. 2003, 91(1-2), 157-66.
  40. Qian, F.; Saidel G.; Sutton, D.; Exner, A.; Gao, J.  Combined Modeling and Experimental Approach for the Development of Dual-release Polymer Millirods.  Journal of Controlled Release. 2002, 83(3), 427-435.
  41. Qian, F.; Nasongkla, N.; Gao, J. Membrane-encased Polymer Millirods for Sustained Release of 5-Fluorouracil.  Journal of Biomedical Materials Research, 2002, 61(2), 203-11.
  42. Qian, F.; Szymanski, A.; Gao, J.  Fabrication and Characterization of Controlled Release Poly(D, L-Lactide-co-Glycolide) Millirods.  Journal of Biomedical Materials Research, 2001, 55(4), 512-522.