李飞 - 中国药科大学 - 药物科学研究院

个人简介

李飞，男，1985年生，博士、副研究员、硕士生导师，天然药物活性组分与药效国家重点实验室成员。2013年毕业于中国药科大学中药学专业，获理学博士学位，并于同年留校任教至今。中国中药协会（China Association of Traditional Chinese Medicine）中药饮片质量保障专业委员会委员，“十二五”普通高校国家级规划教材《中药炮制学》编委。作为课题负责人，先后主持国家自然科学基金青年基金、江苏省自然科学基金青年基金和中央高校基本科研业务项目等课题3项，作为子课题负责人参与并完成医药公司技术服务项目2项，参与十一五、十二五国家重大新药创制专项、国家药典委员会项目、国家自然科学基金项目等课题10余项，指导大学生创新计划项目2项。

研究领域

（1）中药有效成分发现与评价研究；（2）中药炮制机理研究；（3）中药新药开发研究

近期论文

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(1) Li F, Yang Y, Zhu P, Chen W, Qi D, Shi X, Zhang C, Yang Z, Li P. Echinacoside promotes bone regeneration by increasing OPG/RANKL ratio in MC3T3-E1 cells. Fitoterapia.2012, 83: 1443-1450. (2) Yang X#, Li F# (co-first author), Yang Y, Shen J, Zou R, Zhu P, Zhang C, Yang Z, Li P. Efficacy and safety of echinacoside in a rat osteopenia. Evid Based Complement Alternat Med. 2013, 2013: 926928. (3) Li F#, Yang X-L#, Yang Y-N, Guo C-R, Zhang C-F*, Yang Z-L*, Li P. Antiosteoporotic activity of echinacoside in ovariectomized rats. Phytomedicine, 2013, 20: 549-557. (4) Yang X-L#, Yuan Y-N#, Zhang D-M, Li F* and Ye W-C*. Shinjulactone O, a new quassinoid from the root bark of Ailanthus altissima. Nat Prod Res. 2014, 28: 1432-1437. (5) Shen J-Y#, Yang X-L#, Yang Z-L, Kou J-P*, Li F*. Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil. Drug Des Dev Ther. 2015, 9: 4685-4693. (6) Yuan Y-L#, Guo C-R#, Cui L-L, Ruan S-X, Zhang C-F, Ji D, Yang Z-L*, Li F*. Timosaponin B-II ameliorates diabetic nephropathy via TXNI P, mTOR, and NF-κB signaling pathways in alloxan-induced mice. Drug Des Dev Ther. 2015, 9: 6247-6258. (7) Yang M, Yang X-L, An J-M, Xiao W, Wang Z-Z, Huang W-Z, Yang Z-L*, Li F*. Comparative pharmacokinetic profiles of tectorigenin in rat plasma by UPLC-MS/MS after oral administration of Iris tectorum Maxim extract and pure tectoridin. J Pharm Biomed Anal. 2015, 114:34-41. (8) Zhang W-J, Wang J-Y, Li H, He X, Zhang R-Q, Zhang C-F*, Li F*, Yang Z-L, Wang C-Z, Yuan C-S. Novel application of natural anisole compounds as enhancers for transdermal delivery of ligustrazine. Am J Chin Med. 2015, 43:1231-46. (9) Li F#, Yang X-L#, Yang Y-N, Li P, Yang Z-L*, and Zhang C-F *. Phospholipid complex as an approach for bioavailability enhancement of echinacoside. Drug Dev Ind Pharm. 2015, 17: 1-8. (10) Wang X, Song Z-J, He X, Zhang R-Q, Zhang C-F*, Li F*, Wang C-Z, Yuan C-S. Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APCMin/+ mice. Int Immunopharmacol. 2015, 29:701-7. (11) Li F#, Cheng T-F#, Dong X, Li P*, Yang H*. Global analysis of chemical constituents in Shengmai injection using high performance liquid chromatography coupled with tandem mass spectrometry. J Pharm Biomed Anal. 2016, 117:61-72. (12) Du W-J, Yang X-L, Song Z-J, Wang J-Y, Zhang W-J, He X, Zhang R-Q, Zhang C-F*, Li F*, Yu C-H, Wang C-Z, Yuan C-S. Antitumor activity of total flavonoids from daphne genkwa in colorectal cancer. Phytother Res. 2016, 30 (2):323-30. (13) Li F#, Yang X-L#, Bi J-P, Yang Z-L*, Zhang C-F*. Antiosteoporotic activity of Du-Zhong-Wan water extract in ovariectomized rats. Pharm Biol. 2016, 13:1-8. (14) Guo C-R∗, Shen J-Y, Meng Z-Q, Yang X-L, Li F∗. Neuroprotective effects of polygalacicacid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016, 23: 149-155. (15) Cheng T-F, Jia Y-R, Zuo Z, Dong X, Zhou P, Li P*, Li F*. Quality assessment of traditional Chinese medicine herb couple by high-performance liquid chromatography and mass spectrometry combined with chemometrics. J Sep Sci. 2016, 39: 1223–1231. (16) Yuan Y-L, Lin B-Q, Zhang C-F, Cui L-L, Ruan S-X, Yang Z-L*, Li F*, De Ji. Timosaponin B-II Ameliorates Palmitate-Induced Insulin Resistance and Inflammation via IRS-1/PI3K/Akt and IKK/NF-κB Pathways. Am J Chinese Med. 2016, 44: 755–769. (17) Thermal effects on the dissolution enhancement of Radix scutellariae by wine-processing Zhang W-J#, Dong C-L#, Wang J-Y, He X, Yang X-L, Fu Y-F, Zhang C-F*, Li F*, Wang C-Z, Yuan C-S. Appl Therm Eng. 2016, 103: 522–527. (18) Wang J-Y, Dong C-L, Song Z-J, Zhang W-J, He X, Zhang R-Q, Guo C-R, Zhang C-F*, Li F*, Wang C-Z, Yuan C-S. Monocyclic monoterpenes as penetration enhancers of ligustrazine hydrochloride for dermal delivery. Pharm Dev Technol. 2016, 7: 1-7. (19) Wang J-Y#, Ji J#, Song Z-J, Zhang W-J, He X, Li F*, Zhang C-F*, Guo C-R, Wang C-Z, Yuan C-S.Hypocholesterolemic effect of emodin by simultaneous determination of in vitro and in vivo bile salts binding. Fitoterapia. 2016, 110: 116-122.