袁军华 - 中国科学技术大学

个人简介

中国科学技术大学近代物理系，学士加州理工学院（Caltech）物理系，博士哈佛大学分子与细胞生物学系，生物物理，博士后/Research Associate 中国科学技术大学物理系教授/博导，中科院百人计划

研究领域

任何细胞都能对其外界环境的改变作出反应，这是生命现象的基础，而这个信号处理过程是由细胞内的信号网络完成的。当代生物物理的一个重大挑战就是理解这些信号网络的工作机制。为迎接这个挑战，我们结合各种实验和理论手段去寻找一些普遍原理，来解释信号网络的不同架构怎么产生复杂的细胞行为。以细菌行为为例，我们结合各种光学手段（全内反射荧光TIRF、荧光共振能量转移FRET、激光暗场Laser darkfield、超分辨技术Super-resolution techniques、光镊Optical tweezer）、微流体技术、及分子生物学技术，以及统计物理模型，从分子马达到信号传导网络水平上研究分子与细胞行为。我们以细菌趋化(chemotaxis)网络和c-di-GMP网络为例，来研究细胞信号网络。对这两种网络的研究不仅有基础科学上的意义，也有应用前景。细菌的运动及趋化(chemotaxis)行为是细菌致病的必要条件之一，对其深入系统的研究有助于开发新的治疗药物。对鞭毛马达的系统研究也有助于将来人造纳米马达的开发和研制。而c-di-GMP网络参与调节细菌的多种关键生理功能, 包括细胞分化、微生物膜（biofilm）形成、致病因子产生等，对其研究有助于开发新的抗生素。

近期论文

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H. Shi†, S. Ma†, R. Zhang, J. Yuan* (2019) A hidden state in the turnover of a functioning membrane protein complex. Science Advances 5: eaau6885. R. Wang, F. Wang, R. He, R. Zhang*, and J. Yuan* (2018) The Second Messenger c-di-GMP Adjusts Motility and Promotes Surface Aggregation of Bacteria. Biophys. J. 115:2242-2249. C. Zhang†, R. He†, R. Zhang*, and J. Yuan* (2018) Motor adaptive remodeling speeds up bacterial chemotactic adaptation. Biophys. J. 114:1225-1231. B. Wang, R. Zhang, and J. Yuan* (2017) Limiting (zero-load) speed of the rotary motor of Escherichia coli is independent of the number of torque-generating units. PNAS 114:12478-12482. C. Zhang, R. Zhang, and J. Yuan* (2017) Growth-dependent behavioral difference in bacterial chemotaxis. Phys. Rev. E. 95:062404. F. Wang†, H. Shi†, R. He†, R. Wang, R. Zhang*, J. Yuan* (2017) Nonequilibrium effect in the allosteric regulation of the bacterial flagellar switch. Nature Physics 13:710-714. (†:co-first authors) R. He, R. Zhang*, and J. Yuan* (2016) Noise-induced increase of sensitivity in bacterial chemotaxis. Biophys. J. 111:430-437. F. Wang, J. Yuan* and H.C. Berg* (2014) Switching dynamics of the bacterial flagellar motor near zero load. PNAS 111:15752-15755. X. Hua, C. Guo, J. Wang, D. Kim-Holzapfel, B. Schroeder, W. Liu, J. Yuan, J. French, S. Jia* (2018) Depth-extended, high-resolution fluorescence microscopy: whole-cell imaging with double-ring phase (DRiP) modulation. Biomed. Opt. Express 10(1):83-91. T. Si, J. Yuan, Y. Wu, J.X. Tang* (2016) Physical biology of bacterial motility. Acta Physica Sinica 65(17):178703. Y. Yuan et al. (2015) Bridging cells of three colors with two bio-orthogonal click reactions. Chemical Science 6(11):6425-6431. J. Yuan and H.C. Berg (2013) Ultrasensitivity of an adaptive bacterial motor. J. Mol. Biol. 425:1760-1764. J. Yuan and H.C. Berg (2012) Characteriaztion of the adaptation module of the signaling network in bacterial chemotaxis by measurement of step responses. Biophys. J. 103:L31-L33 (Biophysical Letters). J. Yuan, R.W. Branch, B.G. Hosu and H.C. Berg (2012) Adaptation at the output of the chemotaxis signaling pathway. Nature 484:233-236. J. Yuan, K.A. Fahrner, L. Turner and H.C. Berg (2010) Asymmetry in the clockwise and counter-clockwise rotation of the bacterial flagellar motor. PNAS 107:12846-12949. J. Yuan and H.C. Berg (2010) Temperature and solvent-isotope effects on the flagellar rotary motor near zero load. Biophys. J. 98:2121-2126. J. Yuan and H.C. Berg (2010) Following the behavior of the flagellar rotary motor near zero load. Exp. Mech. 50:1263-1265. J. Yuan, K.A. Fahrner and H.C. Berg (2009) Switching of the bacterial flagellar motor near zero load. J. Mol. Biol. 390:394-400. J. Yuan and H.C. Berg (2008) Resurrection of the flagellar rotary motor near zero load. PNAS 105:1182-1185.