Yu, Jin-Quan - The Scripps Research Institute

个人简介

Awards and Honors Member of the American Academy of Arts and Sciences, 2019 Pedler award, Royal Society Chemistry, 2017 MacArthur Genius Grant, 2016 Elias J. Corey Award, American Chemical Scociety, 2014 Raymond and Beverly Sackler Prize in the Physical Sciences, 2013 Fellow of American Association for the Advancement of Science, 2012 Fellow of the Royal Society of Chemistry, 2012 Mukaiyama Award, Society of Organic Synthesis, Japan, 2012 ACS Cope Scholar Award, 2012 Bristol-Myers Squibb Award, 2012 Novartis Early Career Award in Organic Chemistry, 2011 Hirata Memorial Lectureship Medal, Nagoya, 2010 Distinguished Faculty Award of Chinese-American Chemistry & Chemical Biology Professors Association, 2009 Eli Lilly Grantee Award 2008 Amgen Young Investigator's Award 2008 Sloan Research Fellowship 2008 Journal Award for Synlett & Synthesis 2006 Camille and Henry Dreyfus New Faculty Award 2004 Royal Society University Research Fellowship 2003 Fellowship of St John's College, University of Cambridge (JRF) 1998 Sino-British Scholarship by British Council and Education Ministry of China 1994 President Award for Outstanding Students of Chinese Academy of Sciences 1990 Academic Positions Scripps Research Institute - La Jolla, CA, USA Frank and Bertha Hupp Professor of Chemistry, 2012 Professor of Chemistry, 2010 - 2012 Associate Professor of Chemistry, 2007 - 2010 Brandeis University - Waltham, MA, USA Assistant Professor of Chemistry, 2004 - 2007 University of Cambridge - Cambridge, UK Royal Society Research Fellow, 2003 - 2004 Education Harvard University - Cambridge, MA, USA Postdoctoral Fellow, supervisor: E.J. Corey February 2001 - May 2002 University of Cambridge - Cambridge, UK Junior Research Fellow (JRF) of St. John's College October 1999 - October 2003 University of Cambridge - Cambridge, UK Ph.D. in Chemistry with Jonathan Spencer October 1994 - September 1999 Guangzhou Institute of Chemistry - Guangzhou, China M.Sc. in Chemistry with S.D. Xiao September 1988 - July 1990 Shanghai Institute of Organic Chemistry - Shanghai, China Coursework for M.Sc. degree September 1987 - July 1988 East China Normal University - Shanghai, China B.Sc. in Chemistry Top 5% of national examination for admission to SIOC Supervisors: L.X. Dai and B.Q. Wu September 1982 - July 1987

研究领域

Discovery and rational design of new reactions using C-H activation Our program centers around the discovery of catalytic carbon-carbon and carbon-heteroatom bond forming reactions based on C-H activation. Target transformations are selected to enable 1) the use of simple and abundant starting materials such as aliphatic acids, amines and alcohols, and 2) disconnections that drastically shorten the synthesis of a drug molecule or a major class of biologically active compounds. Ultimately, we hope to develop catalytic reactions to parallel enzymatic transformations in terms of reactivity and selectivity. To achieve this goal, our research activities are directed towards the following central challenges: 1) C-H activation of broadly useful substrates initiated by weak coordination and ligand acceleration; 2) Achieving site-selective remote C-H activation using distance and geometry as the key differentiating parameters; 3) Establishing new stereomodel and developing chiral ligands to enable enantioselective C-H activation via metal insertion.

近期论文

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Andra, M. S., Schifferer, L., Pollok, C. H., Merten, C., Goossen, L. J., Yu, J. Q. Enantio- and diastereoswitchable C-H arylation of methylene groups in cycloalkanes Chemistry-a European Journal 2019 25:8503-8507 DOI:10.1002/chem.201902046 PMID:31062889 PMCID:PMC6634307 Kang, Y. S., Zhang, P., Li, M. Y., Chen, Y. K., Xu, H. J., Zhao, J., Sun, W. Y., Yu, J. Q., Lu, Y. Ligand-promoted RhIII -catalyzed thiolation of benzamides with a broad disulfide scope Angewandte Chemie-International Edition 2019 58:9099-9103 DOI:10.1002/anie.201903511 PMID:31124280 Liu, L. Y., Yeung, K. S., Yu, J. Q. Ligand-promoted non-directed C-H cyanation of arenes Chemistry-a European Journal 2019 25:2199-2202 DOI:10.1002/chem.201805772 PMID:30478935 Shang, M., Feu, K. S., Vantourout, J. C., Barton, L. M., Osswald, H. L., Kato, N., Gagaring, K., McNamara, C. W., Chen, G., Hu, L., Ni, S., Fernandez-Canelas, P., et al. Modular, stereocontrolled Cβ-H/Cα-C activation of alkyl carboxylic acids Proceedings of the National Academy of Sciences of the United States of America 2019 116:8721-8727 DOI:10.1073/pnas.1903048116 PMID:30996125 Carreira, E. M., Ding, K., Brimble, M., Liu, H., Chiu, P., Maulide, N., Prasad, K. R., Xi, Z., Reisman, S. E., Yamaguchi, S., Ritter, T., Yu, J. Q. Organic Letters 2.0: A new beginning Organic Letters 2019 21:1-4 DOI:10.1021/acs.orglett.8b03964 Hu, L., Shen, P., Shao, Q., Hong, K., Qiao, J., Yu, J. Q. Pd-II-catalyzed enantioselective C(sp(3))-H activation/cross-coupling reactions of free carboxylic acids Angewandte Chemie-International Edition 2019 58:2134-2138 DOI:10.1002/anie.201813055 PMID:30536546 Li, M., Shang, M., Xu, H., Wang, X., Dai, H. X., Yu, J. Q. Remote para-C-H acetoxylation of electron-deficient arenes Organic Letters 2019 21:540-544 DOI:10.1021/acs.orglett.8b03871 PMID:30615468 Xu, H. J., Kang, Y. S., Shi, H., Zhang, P., Chen, Y. K., Zhang, B., Liu, Z. Q., Zhao, J., Sun, W. Y., Yu, J. Q., Lu, Y. Rh(III)-catalyzed meta-C-H alkenylation with alkynes Journal of the American Chemical Society 2019 141:76-79 DOI:10.1021/jacs.8b11038 PMID:30585063 Xu, J., Chen, J., Gao, F., Xie, S., Xu, X., Jin, Z., Yu, J. Q. Sequential functionalization of meta-C-H and ipso-C-O bonds of phenols Journal of the American Chemical Society 2019 141:1903-1907 DOI:10.1021/jacs.8b13403 PMID:30665300 Chen, X. Y., Wu, Y., Zhou, J., Wang, P., Yu, J. Q. Synthesis of β-arylethenesulfonyl fluoride via Pd-catalyzed nondirected C-H alkenylation Organic Letters 2019 21:1426-1429 DOI:10.1021/acs.orglett.9b00165 PMID:30785296 Hill, D. E., Pei, Q. L., Zhang, E. X., Gage, J. R., Yu, J. Q., Blackmond, D. G. A general protocol for addressing speciation of the active catalyst applied to ligand-accelerated enantioselective C(sp(3))-H bond arylation ACS Catalysis 2018 8:1528-1531 DOI:10.1021/acscatal.8b00103 Park, H., Verma, P., Hong, K., Yu, J. Q. Controlling Pd(IV) reductive elimination pathways enables Pd(II)-catalysed enantioselective C(sp(3))-H fluorination Nature Chemistry 2018 10:755-762 DOI:10.1038/s41557-018-0048-1 PMID:29892027 Xu, L. L., Wang, X., Ma, B., Yin, M. X., Lin, H. X., Dai, H. X., Yu, J. Q. Copper mediated C-H amination with oximes: en route to primary anilines Chemical Science 2018 9:5160-5164 DOI:10.1039/c8sc01256c Kong, W. J., Shao, Q., Li, M. H., Zhou, Z. L., Xu, H., Dai, H. X., Yu, J. Q. Copper-mediated diastereoselective C-H thiolation of ferrocenes Organometallics 2018 37:2832-2836 DOI:10.1021/acs.organomet.8b00457 Saint-Denis, T. G., Zhu, R. Y., Chen, G., Wu, Q. F., Yu, J. Q. Enantioselective C(sp(3))-H bond activation by chiral transition metal catalysts Science 2018 359 DOI:10.1126/science.aao4798 PMID:29449462 Wu, Q. F., Wang, X. B., Shen, P. X., Yu, J. Q. Enantioselective C-H arylation and vinylation of cyclobutyl carboxylic amides ACS Catalysis 2018 8:2577-2581 DOI:10.1021/acscatal.8b00069 PMID:29531850 PMCID:PMC5844484 Shi, H., Herron, A. N., Shao, Y., Shao, Q., Yu, J. Q. Enantioselective remote meta-C-H arylation and alkylation via a chiral transient mediator Nature 2018 558:581-585 DOI:10.1038/s41586-018-0220-1 PMID:29915312 PMCID:PMC6026055 Shao, Q., Wu, Q. F., He, J., Yu, J. Q. Enantioselective γ-C(sp3)-H activation of alkyl amines via Pd(II)/Pd(0) catalysis Journal of the American Chemical Society 2018 140:5322-5325 DOI:10.1021/jacs.8b01094 PMID:29629766 PMCID:PMC5927623 Lu, M. Z., Chen, X. R., Xu, H., Dai, H. X., Yu, J. Q. Ligand-enabled ortho-C-H olefination of phenylacetic amides with unactivated alkenes Chemical Science 2018 9:1311-1316 DOI:10.1039/c7sc04827k Zhuang, Z., Yu, C. B., Chen, G., Wu, Q. F., Hsiao, Y., Joe, C. L., Qiao, J. X., Poss, M. A., Yu, J. Q. Ligand-enabled β-C(sp3)-H olefination of free carboxylic acids Journal of the American Chemical Society 2018 140:10363-10367 DOI:10.1021/jacs.8b06527 PMID:30029574 Zhu, R. Y., Li, Z. Q., Park, H. S., Senanayake, C. H., Yu, J. Q. Ligand-enabled γ-C(sp3)-H activation of ketones Journal of the American Chemical Society 2018 140:3564-3568 DOI:10.1021/jacs.8b01359 PMID:29481072 PMCID:PMC5851877