周浩 - 南开大学 - 生命科学学院

个人简介

周浩，副教授，硕士生导师。于2003年毕业于湖北农学院生物技术专业，获得学士学位；于2008年毕业于南开大学生物化学与分子生物学系，获得博士学位。同年留校任讲师，2013年12月晋升为副教授。2017年3月以访问学者身份到德州大学安德森癌症研究中心癌症生物学系从事研究和学习工作。研究方向为蛋白质结构与功能。主持国家自然科学基金青年基金等科研项目2项，发表学术论文多篇，包括以第一作者或通讯作者在Cell Res，JMB，Plos One等国际一流杂志期刊上发表的论文。现为中国生物化学与分子生物学学会会员。教育经历 1999.9-2003.6 湖北农学院生物技术专业获得学士学位； 2003.9-2008.6 南开大学生物化学与分子生物学专业获得博士学位。工作经历 2008.7-2013.12年南开大学生命科学学院讲师； 2013.12-至今南开大学生命科学学院副教授硕士生导师。

研究领域

蛋白质结构与功能；基于结构的蛋白质工程及应用。

近期论文

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[1] Xing W, Li M, Zhang F, Ma X, Long J, Zhou H. The conformation change and tumor suppressor role of Merlin are both independent of Serine 518 phosphorylation[J]. Biochem Biophys Res Commun, 2017, 493(1): 46-51. [2] Qu A, Huang F, Li A, Yang H, Zhou H, Long J, Shi L. The synergistic effect between KLVFF and self-assembly chaperones on both disaggregation of beta-amyloid fibrils and reducing consequent toxicity[J]. Chem Commun (Camb), 2017, 53(7): 1289-1292. [3] Zheng M, Xing W, Liu Y, Li M, Zhou H. Tetramerization of SATB1 is essential for regulating of gene expression[J]. Mol Cell Biochem, 2017, 430(1-2): 171-178. [4] Liu S, Zhou D, Yang J, Zhou H, Chen J, Guo T. Bioreducible Zinc(II)-Coordinative Polyethylenimine with Low Molecular Weight for Robust Gene Delivery of Primary and Stem Cells[J]. 2017, [5] Dong C, Tang X, Xie Y, Zou Q, Yang X, Zhou H. The crystal structure of an inactive dimer of PDZ-binding kinase[J]. Biochem Biophys Res Commun, 2016, 476(4): 586-593. [6] Ren H, Liu S, Yang J, Zhang X, Zhou H, Chen J, Guo T. N,N,N-trimethylchitosan modified with well defined multifunctional polymer modules used as pDNA delivery vector[J]. Carbohydr Polym, 2016, 137(222-230. [7] Liu S, Yang J, Ren H, O'Keeffe-Ahern J, Zhou D, Zhou H, Chen J, Guo T. Multifunctional oligomer incorporation: a potent strategy to enhance the transfection activity of poly(l-lysine)[J]. Biomater Sci, 2016, 4(3): 522-532. [8] Zhang X, Dong C, Huang W, Wang H, Wang L, Ding D, Zhou H, Long J, Wang T, Yang Z. Rational design of a photo-responsive UVR8-derived protein and a self-assembling peptide-protein conjugate for responsive hydrogel formation[J]. Nanoscale, 2015, 7(40): 16666-16670. [9] Wang H, Wang Y, Zhang X, Hu Y, Yi X, Ma L, Zhou H, Long J, Liu Q, Yang Z. Supramolecular nanofibers of self-assembling peptides and proteins for protein delivery[J]. Chem Commun (Camb), 2015, 51(75): 14239-14242. [10] Xu H, Lin Z, Li F, Diao W, Dong C, Zhou H, Xie X, Wang Z, Shen Y, Long J. Dimerization of elongator protein 1 is essential for Elongator complex assembly[J]. Proc Natl Acad Sci U S A, 2015, 112(34): 10697-10702. [11] Shi Y, Zhou H, Zhang X, Wang J, Long J, Yang Z, Ding D. Self-assembling choline mimicks with enhanced binding affinities to C-LytA protein[J]. Sci Rep, 2014, 4(6621. [12] Li Y, Zhou H, Li F, Chan S W, Lin Z, Wei Z, Yang Z, Guo F, Lim C J, Xing W, Shen Y, Hong W, Long J, Zhang M. Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway[J]. Cell Res, 2015, 25(7): 801-817. [13] Dong C, Lin Z, Diao W, Li D, Chu X, Wang Z, Zhou H, Xie Z, Shen Y, Long J. The Elp2 subunit is essential for elongator complex assembly and functional regulation[J]. Structure, 2015, 23(6): 1078-1086. [14] Chen J, Zhou H, Wang J, Zhang B, Liu F, Huang J, Li J, Lin J, Bai J, Liu R. Therapeutic effects of resveratrol in a mouse model of HDM-induced allergic asthma[J]. Int Immunopharmacol, 2015, 25(1): 43-48. [15] Zhang X, Zhou H, Xie Y, Ren C, Ding D, Long J, Yang Z. Rational design of multifunctional hetero-hexameric proteins for hydrogel formation and controlled delivery of bioactive molecules[J]. Adv Healthc Mater, 2014, 3(11): 1804-1811. [16] Lv C, Gao X, Li W, Xue B, Qin M, Burtnick L D, Zhou H, Cao Y, Robinson R C, Wang W. Single-molecule force spectroscopy reveals force-enhanced binding of calcium ions by gelsolin[J]. Nat Commun, 2014, 5(4623. [17] Du X, Wang J, Diao W, Wang L, Long J, Zhou H. A genetically modified protein-based hydrogel for 3D culture of AD293 cells[J]. PLoS One, 2014, 9(9): e107949. [18] Jiang D, Zhang Q, Zheng Q, Zhou H, Jin J, Zhou W, Bartlam M, Rao Z. Structural analysis of Mycobacterium tuberculosis ATP-binding cassette transporter subunit UgpB reveals specificity for glycerophosphocholine[J]. Febs j, 2014, 281(1): 331-341. [19] Wang J, Zhang J, Zhang X, Zhou H. A protein-based hydrogel for in vitro expansion of mesenchymal stem cells[J]. PLoS One, 2013, 8(9): e75727. [20] Chu X, Qin X, Xu H, Li L, Wang Z, Li F, Xie X, Zhou H, Shen Y, Long J. Structural insights into Paf1 complex assembly and histone binding[J]. Nucleic Acids Res, 2013, 41(22): 10619-10629.