段少峰 - 河南大学

个人简介

受教育经历 (Educational Experience) （从大学本科开始，按时间倒排序）：　　2002.08-2007.10，新墨西哥州立大学，化学与生物化学系，博士（有机化学）　　1998.09-2000.10，华东理工大学，精细化工研究所，攻读博士　　1995.09-1998.04，南京理工大学，化工学院，硕士（应用化学）　　1991.09-1995.07，南京理工大学，化工学院，本科（精细化工）工作经历 (Professional Experience) （按时间倒排序）：　　2015.09-至今，河南大学药学院，教授，黄河学者特聘教授　　2010.05-2015.08，美国堪萨斯大学药学院，副研究员　　2008.11-2010.05，美国堪萨斯大学药学院，博士后　　2007.10-2008.11，美国堪萨斯大学药学院，博士后

研究领域

1）小分子抗癌药的设计与合成；2）纳米高分子药物载体的设计与合成；3）抗癌前药的合成及药物控释。

近期论文

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[1]Shengnan Huang#, Shaofeng Duan#, Jing Wang, Shijin Bao, Xiaojing Qiu, Chunming Li, Ying Liu, Lijuan Yan, Zhenzhong Zhang,Yurong Hu. Folic Acid Mediated Functionalized Gold Nanocages for Targeted Delivery of Anti-miR-181b in Combination of Gene Therapy and Photothermal Therapy against Hepatocellular Carcinoma. Advanced Functional Materials 2016 26(15), 2532-2544　　[2]Solomon Z Okbazghi, Apurva S More, Derek R White, Shaofeng Duan, Ishan S Shah, Sangeeta B Joshi, C Russell Middaugh, David B Volkin, Thomas J Tolbert. Production, Characterization, and Biological Evaluation of Well-Defined IgG1 Fc Glycoforms as a Model System for Biosimilarity Analysis. J Pharm. Sci. 2016 105(2), 559-74.　　[3]Yunqi Zhao, Ti Zhang#, Shaofeng Duan#, Neal M Davies, M Laird Forrest. CD44-tropic polymeric nanocarrier for breast cancer targeted rapamycin chemotherapy. Nanomedicine 2014 10(6), 1221-30.　　[4]Lohrman, Jessica; Liu, Yueying; Duan, Shaofeng; Zhao, Xiaoyong; Wuttig, Manfred; Ren, Shenqiang; All Conjugated Copolymer Excitonic Multiferroics. Advanced Materials 2013 25 (5), 783-787.　　[5]Ndolo, Rosemary A.; Luan, Yepeng; Duan, Shaofeng; Forrest, M. Laird; Krise, Jeffrey P. Lysosomotropic properties of weakly basic anticancer agents promote cancer cell selectivity in vitro. PLoS One 2012 7(11), e49366.　　[6]SM Cohen, R Mukerji, S Duan, S Cai, ML Forrest, MS CohenM. Laird Forrest. A Novel Nanocarrier Delivery System for Doxorubicin with Improved Tumor Response and Reduced Systemic Toxicity in Advanced Pediatric Non-Hodgkin Lymphoma. Journal of Surgical Research. 2012 172 (2), 317.　　[7]Yunqi Zhao#, Shaofeng Duan#, Xing Zeng, Chunjing Liu, Benyi Li, Neal M. Davies, M Laird Forrest. Prodrug Strategy for PSMA-targetted Delivery of TGX-221 to Prostate Cancer Cells. Molecular Pharmaceutics. 2012, 9, 1705−1716.　　[8]Taryn R. Bagby#, Shaofeng Duan#, Shuang Cai, Laird Forrest. Functional lymphatic imaging using negatively charged star polymer architectures grafted with near-infrared dye. European Journal of Pharmaceutical Sciences 2012, 47(1), 287-294.　　[9]Taryn R. Bagby, Shuang Cai, Shaofeng Duan, Sharadvi Thati, Aires, Daniel J., Laird Forrest. Impact of molecular weight on lymphatic drainage of a biopolymer-based imaging agent. Pharmaceutics 2012, 4(2), 276-295.　　[10]Shaofeng Duan, Shuang Cai, Yumei Xie, M. Laird Forrest. Ester star polymers as controlled drug release carriers for cisplatin and nitric oxide. Journal of Polymer Science Part A: Polymer Chemistry 2012, 50, 2715–2724.　　[11]Shaofeng Duan, Shuang Cai, Qiuhong Yang, M. Laird Forrest. Multi-arm polymeric nanocarrier as a nitric oxide delivery platform for chemotherapy of head and neck squamous cell carcinoma. Biomaterials 2012, 33, 3243-3253.　　[12]Yepeng Luan, Qiuhong Yang, Yumei Xie, Shaofeng Duan, M.L Forrest. A Sensitive Near-Infrared Fluorescent Probe for Caspase-mediated Apoptosis: Synthesis and Application in Cell Imaging. Drug Discoveries & Therapeutics 2011, 5(5), 220-226.　　[13]Rajesh Kumar Patti, Shaofeng Duan, Zhipeng Wang, James W. Herndon. Preparation of phenalenes and hydronaphthacenes through tandem alkyne Fischer–carbene complex coupling and inter- or intra-molecular Diels–Alder reactions. Tetrahedron Lett. 2011, 52(32), 4182-4185.　　[14]Rajesh Kumar-Patti, Shaofeng Duan, Alejandro Camacho-Davila, Kris Waynant, Kenneth A Dunn, James W Herndon. Synthesis of hydronaphthalenes through coupling of enyne carbonyl compounds that contain pendant alkene groups with Fischer carbene complexes. Tetrahedron Lett. 2010, 51(28), 3682-3684.　　[15]Xie, Yumei, Duan, Shaofeng, Forrest, M. Laird. Alkyne- and 1, 6-elimination-succinimidyl carbonate-terminated heterobifunctional poly (ethylene glycol) for reversible "click" PEGylation. Drug Discoveries & Therapeutics 2010, 4(4), 240-245.　　[16]Sandipan Sinha, Lei Zhang, Shaofeng Duan, Todd Williams, Josef Vlasak, Roxana Lonescu, Elizabeth Topp. Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody. Protein Science 2009, 18(8), 1573-1584.　　[17]Shaofeng Duan, Ranjan Jana, Jon Tunge. “Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters” J. Org. Chem. 2009, 74, 4612–4614.　　[18]Shaofeng Duan, Dilip K. Sinha-Mahapatra, James W. Herndon. “Synthesis of Nanphthalenes through three-component coupling of alkynes, Fischer carbene complexes and Benzaldehyde Hydrozones via Isoindole intermediates” Org. Lett. 2008, 10, 1541-1544.