个人简介

B.S. (1981) University of Missouri – St. Louis Ph.D. (1985) University of Missouri – St. Louis Postdoctoral Fellow. ('85–'87) Cornell University

研究领域

Analytical Chemistry; Inorganic Chemistry

Evaluating Biomarkers of Inflammation of Cardiovascular Risk The purpose of this research is to understand how gender differences are manifested in cardiac vascular risk. More specifically, are the current clinical risk assessment tools sufficient for therapeutic recommendations? Our hypothesis is that the state of inflammation in cardiac tissues from a variety of metabolic factors and disease provides a more reliable risk assessment tool. Therefore, analytical tools to quantitatively assess the levels of inflammation will be developed; and these methods will be applied to understanding the development of cardiovascular disease and related gender differences using a rat model. Inflammation in Tumor Progression We are interested in the molecular mechanisms that regulate tumor progression in colon cancer. Currently we are developing bioanalytical methods to quantify major eicosanoids that regulate inflammation and tumor growth. Profiling the Course of Hypertensive Disease Determination of creatinine and 8-iso PGF2 from the same urine sample is efficient. Levels of urinary isoprostane and creatinine are markers of disease progression as is age. In this study, levels of inflammatory biolipids are quantified and correlated with levels of natural sex hormone to profile progression of disease from hypertensive conditions. Understanding Inflammation in Brain Injury and Disease We are interested in understand how resolution of inflammation encourages recovered from traumatic brain injury and how the availability of brain active biolipids affects brain function

近期论文

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Stull, J., Majerich, D., Smythe, A., Varnum, S & Gilles T. (In Press). “Examination of Instructional Time Allocations and Student Engagement for Grades K-16 Science, Mathematics, and Education Classes.” International Journal of Science in Society. Stull, J., Varnum, S., Ducette, J., Shiller, J., & Bernacki, M. (In Press). The many faces of formative assessment. The International Journal for Teaching and Learning in Higher Education. Majerich, D., Stull, J., Varnum, S., Gilles, T., & Ducette, J. (2011). Facilitation of formative assessments using clickers in a university physics course. Interdisciplinary Journal of E-Learning and Learning Objects, 7, 11-24. Williamson, S., Varma, D., Brown, M.D., & Jansen, S. (2011). Eicosanoid Production Following One Bout of Exercise in African American Pre- and Stage 1 Hypertensives. Journal of Aging Research, 2011, 7 pages. Varma, D., Ganti S., Gilles, T., Diaz, M., Thompson, T., Stull, J., Jansen, SA. (2011). Comparison of UHPLC and HPLC Methods for the Assay of Prostanoids “Are the methods equivalent in terms of their accuracy and precision?” Bioanalysis. 3(8), 853-862. Blewett, A. J., Jansen, S.A., Varma, D., Gilles, T., Butcher, R.*, Jacob, J.*, & Amazon, J.* (2011). Development and validation of a stability indicating high-performance liquid chromatography method for the simultaneous analysis of albuterol, budesonide, and ipratropium bromide in extemporaneous compounded nebulizer solutions. Journal of AOAC International. 94(1), 1-8. Ansong, Omari; Jansen, Susan; Wei, Yen; Pomrink, Gregory; Lu, Hui; Patel, Alpa; Li, Shuxi, “Additive enhanced controlled and living free radical polymerization of methacrylates by stabilized nitroxide unimolecular initiators. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 49(2), 3-4, 2009. Ansong, O, Jansen, S, Wei, Y, Pomrink, G., Lu, H., Patel, A., Li, S., “ Accelerated controlled radical polymerization of methacrylates”, Polymer Int., 58, 1 54-65, 2009. Ketelhut, D., Schifter, C., Jansen Varnum, S. & Stull, J. (2009). Introducing interactive whiteboards to urban teachers. In I. Gibson et al. (Eds.), Proceedings of Society for Information Technology & Teacher Education International Conference 2009 (pp. 3789-3792). Chesapeake, VA: AACE. Blewett, AJ, Varma, D., Gilles, T., Libonati, J, Jansen, S., ”Development and validation of a high-performance liquid chromatography electrospray mass spectrometry methods for the simultaneous determination of 223 eicosanoids”. J. Pharm Biomed Anal., 46, 4, 653-662, 2008. Ansong, O, Jansen, S, Wei, Y., Pormink, G., Li, S., Patel, A., “ Accelerant-promoted free radical polymreization of methacrylates by stabilized nitroxide unimolecular initiators: synthesis and characterization”. Polymer Int. 57, 6, 863-871, 2008. Yue, H, Jansen, SA, Strauss, KI, Borenstein, MR, Barbe, MF, Rossi, LJ, Murphy, E., “A liquid chromatography method for simulataneous analysis of endogenous eicosanoid metabolites prostaglandins, dihydroxyeicosatrienoic acids, hyrdroxyeicosatetraenoic acids and epoxyeicosatrienoic aicds,” Journal of Pharmaceutical and Biomedical Analysis, 43(3), 1122, 2007. Ansong, Omari, Wei, Yen, Pomrink, G. Lu, H, Li, S. Guo, Li, Jansen, S., “Novel –acyloxytrialkylammonium salts as initiators or methacrylates,” J. Mat. Chem, 2007. Hongfei Yue, Michael R. Borenstein, Susan A. Jansen and Robert B. Raffa, “LC/MS Analysis of Buprenorphine and its N-dealkylated Metabolite Norbuprenorphine in Mouse Brain Tissue and Plasma , J. Pharm. Tox. Methods, 2005, 314-322. Gopez, JJ, Yue, H., Vasudevan, R, Malik, AS, Fogelsanger, LN, Lewis, S., Paniskashvili, D., Shohami, E, Jansen, SA, Narayan, RK, Strauss, KI, “Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection and reduces inflammation in a rat model of traumatic brain injury, Neurosurgery, 56(3), 590-603, 2005. Sein, L.T., Jr., Wei, Y, Jansen, SA, “Corrosion Inhibition by Aniline Oligomers through Charge Transfer : A DFT Approach”, Syn. Met., 143, 2004, 1-12. DiCicco, M., Goldfinger, A., Guirand, F. Abdullah, A, Jansen, S., “In-Vitro Tobramycin Elution Analysis from a Novel b-Tricalcium Phosphate-Silicate-Xerogel Biodegradable Drug Delivery system”, J. Biomedical Materials Research, 70B, 1-20. Yue, H., Strauss, KI, Borenstein, MR, Barbe, MF, Rossi, L, Jansen, S., “Determination of Bioactive Eicosanoids in Brain Tissue by a Sensitive Reversed-Phase LC Method with Fluorescence Detection”, J. Chrom. B, 803, 2004, 267-277. DiCicco, M., Compton, R. Jansen-Varnum, SA, “In-vitro Evaluation of Orthopedic Cytoxicity : Assess the Potential for Postsurgical Production of Hydroxyl Radicals”, J. Biomedical Materials Research, 72B, 1-20., 2004. DiCicco, M. Duong, T., Chu, A., Jansen, SA, “Tobramycin and Gentamycin Elution Analysis Between Two in-situ Polymerizable Orthopedic Composites”, J. Biomed. Mater. Res. B, 2003, 65B, 137-149.