个人简介

1978.03-1982.07 Department of biology, University of Science and Technology of China; undergraduate student; speciality: Cell Biology 1982.10-1985.08 Wuhan Institute of Virology, Academia Sinica, Wuhan Assistant Researcher (Research on ds-RNA of Rota-virus and preservation technique of plant viruses) 1985.09-1988.10 Institute of Biophysics, Academia Sinica, Beijing Graduate student for Master Degree; speciality: Molecular Biology 1988.11-present School of Life Science, University of Science and Technology of China (NMR methodology, Structure determination of protein and nucleic acid) 1995.01-1996.01 Institut fuer Molekularbiologie und Biophysik, ETH, Switzerland Advanced study for NMR and Structure Determination of Protein

研究领域

NMR methodology; the conformation and dynamics property of protein and nucleic acid studied by NMR and computer simulation methods.

蛋白质和核酸的核磁共振研究及生物核磁共振波谱学方法学研究，特别是蛋白质的结构测定及结构和功能关系，以及蛋白质-蛋白质，蛋白质-核酸，蛋白质-配基相互作用,结构基因组学研究中适于高通量结构测定以及代谢组学中的核磁共振方法学研究。

近期论文

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1. Qingtao Wei, Jiajing Chen, Juan Mi, Jiahai Zhang, Ke Ruan,* and Jihui Wu*, NMR Backbone Assignment of Large Proteins by Using 13Ca-Only Triple-Resonance Experiments. Chem. Eur. J. (2016) 22, 9556-9564 2. HongyuBao, FudongLi, ChongyuanWang, NaWang, YiyangJiang, YajunTang, JihuiWu*, and YunyuShi*，Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3. Journal of Biological Chemistry (2016) 291(32),16709-16719 3. Zhonghua Liu, Fudong Li, Beibei Zhang, Sai Li, Jihui Wu# and Yunyu Shi#, Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. Journal of Biological Chemistry (2015) 290:6630-6638 4. Chongyuan Wang, Yuwei Zhu, Hongyu Bao, Yiyang Jiang, Chao Xu, Jihui Wu* and Yunyu Shi*, A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1. Nucleic Acids Research (2015) 44(2): 969-982 5. Fudong Li, Debiao Zhao, Jihui Wu, Yunyu Shi. Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition. Cell Research (2014) 24:1490-1492 6. ChongyuanWang, YuweiZhu, TamarB.Caceres, LeiLiu, JunhuiPeng, JunchenWang, JiajingChen, XuwenChen, Zhiyong Zhang, Xiaobing Zuo, Qingguo Gong, Maikun Teng, Joan M. Hevel, Jihui Wu and Yunyu Shi. Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7. Structure (2014)22,756–768,May 6, 2014 7. He Chao, Li Fudong, Zhang Jiahai, Wu Jihui, Shi Yunyu. Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition. J Biol Chem, 2013,288(7):4692-703 8. Yu Qiu, Lei Liu, Chen Zhao, Chuanchun Han, Fudong Li, Jiahai Zhang, Yan Wang, Guohong Li, Yide Mei, Mian Wu, Jihui Wu, and Yunyu Shi. Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes & Development (2012)26:1376-1391 9. Jie Wen, Pei Zhou, Jihui Wu. Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl-methyl NOESY for large proteins. Journal of Magnetic Resonance (2012)218:128-132 10. Yu QIU, Wen ZHANG, Chen ZHAO, Yan WANG, Weiwei WANG, Jiahai ZHANG, Zhiyong ZHANG, Guohong LI, Yunyu SHI, Xiaoming TU and Jihui WU. Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA. Biochem.J. (2012)442,527-538