Zheng, Siyang - The Pennsylvania State University - Department of Biomedical Engineering

个人简介

Dr. Siyang Zheng is an Associate Professor in the department of Biomedical Engineering at the Pennsylvania State University, University Park, PA, USA. He received his B.S. in Biological Sciences and Biotechnology from Tsinghua University, Beijing, China in 1996, received his M.S. in Electrical Engineering from the Pennsylvania State University, University Park, PA, USA in 2000. He worked as a Member of Technical Staff I for Lucent Technologies at Holmdel, NJ in 2001. He received his Ph.D. in Electrical Engineering from the California Institute of Technology, Pasadena, CA, USA in 2007. He continued with his postdoctoral study until the end of 2008 at the California Institute of Technology. Among other honors he was awarded the National Institutes of Health (NIH) Director’s New Innovator Award in 2012.

研究领域

The Penn State MINIBio Lab aims at developing and applying micro/nano technologies for biological and medical applications. On one hand, we are interested in studying miniaturized devices and systems that can be integrated with biological system in vitro and in vivo. On the other hand, we are eager to apply these technologies for fundamental biological research and clinic diagnosis and treatment. The research is highly multidisciplinary, interfacing at engineering, biological sciences, physical sciences, and medicine. Current research focuses of the group include: Micro/nano materials, devices and systems for liquid biopsy-based cancer diagnosis, including enrichment and analysis of circulating tumor cells (CTCs) and extracelluar vesicles (EVs) Nanomaterials and nanomaterial integrated microdevices for infectious disease diagnosis and pathogen discovery Nanomaterials and implantable devices for drug delivery and disease monitoring Nanomaterials for proteomics including peptide capture and ultrafast protein digestion Lab-on-chip biomarker detection in body fluid High-performance devices for gas chromatography (GC) and volatile organic compound (VOC) detection

近期论文

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Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins, G. Cheng, W. Li, L. Ha, X. Han, S. Hao, Y. Wan, Z. Wang, F. Dong, X. Zou, Y. Mao, & S.-Y. Zheng, Journal of the American Chemical Society, 140, 7282-7291, 2018. (Feature as supplementary cover story) Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug, W.-Q. Li, Z. Wang, S. Hao, L. Sun, M. Nisic, G. Cheng, C. Zhu, Y. Wan, L. Ha, L. & S.-Y. Zheng, Nanoscale, 10, 3744-3752, 2018. Light-emitting transition metal dichalcogenide monolayers under cellular digestion, Y.-T. Yeh, Y. Tang, Z. Lin, K. Fujisawa, Y. Lei, Y. Zhou, C. Rotella, A. L. Elias, S.-Y. Zheng, Y. Mao, Z. Liu, H. Lu, & M. Terrones, Advanced Materials, 30, 1703321, 2018. A spontaneous 3D bone-on-a-chip for bone metastasis study of breast cancer cells, S. Hao, L. Ha, G. Cheng, Y. Wan, Y. Xia, D. M. Sosnoski, A. M. Mastro, and S.-Y. Zheng, Small, 14, 1702787, 2018. Pre-occupation of empty carriers decreases endo/lysosome escape and reduces the protein delivery efficiency of mesoporous silica nanoparticles, W. Li, L. Sun, Y. Xia, S.-J. Hao, G. Cheng, Z. Wang, Y. Wan, C. Zhu, H. He, and S.-Y. Zheng, ACS Applied Materials & Interfaces, 10, 5340-5347, 2018. Size-based separation methods of circulating tumor cells, S.-J. Hao, Y. Wan, Y.-Q. Xia, X. Zou, and S.-Y. Zheng, Advanced Drug Delivery Reviews, 25, 3-20, 2018. In situ caging of biomolecules in graphene hybrids for light modulated bioactivity, G. Cheng, X.-H. Han, S.-J. Hao, M. Nisic, and S.-Y. Zheng, ACS Applied Materials & Interfaces, 10, 3361-3371, 2018. Aptamer conjugated extracellular nanovesicles for in vivo targeted drug delivery, Y. Wan, L. Wang, C. Zhu, Q. Zheng, G. Wang, J. Tong, Y. Fang, Y.-Q. Xia, G. Cheng, X. He, and S.-Y. Zheng, Cancer Research, 78, 798-808, 2018. Chopper-Modulated gas chromatography electroantennography enabled using high-temperature MEMS flow control device, M.-D. Zhou, M. Akbar, A. J. Myrick, Y. Xia, W. J. Khan, X. Gao, T. C. Baker and S.-Y. Zheng, Microsystems & Nanoengineerin, Nature Publishing Group, 3, 17062, 2017. Rapid isolation of extracellular vesicles via lipid nanoprobes, Y. Wan, G. Cheng, X. Liu, S.-J. Hao, M. Nisic, C.-D. Zhu, Y.-Q.Xia, W.-Q. Li, Z.-G. Wang, W.-L. Zhang, S. J. Rice, A. Sebastian, I. Albert, C. P. Belani, S.-Y. Zheng, Nature Biomedical Engineering, 1, 0058, 2017. (Feature as front cover story) Self-assembly of smart multifunctional hybrid compartments with programmable bioactivity, G. Cheng, S.-J.Hao, Y. Wan, D.-Y.Shan, J. Yang, S.-Y. Zheng, Chemistry of Materials, 29 (5), 2081-2089, 2017. Evaluating a novel dimensional reduction approach for mechanical fractionation of cells using a tandem flexible micro spring array (tFMSA), Y. T. Yeh, R. A. Harouaka, S. -Y. Zheng, Lab on a Chip, 17 (4), 691-701, 2017. Label-free virus capture and release by a microfluidic device integrated with porous silicon nanowire forest, Y. Xia, Y. Tang, X. Yu, Y. Wan, Y. Chen, H. Lu, S.-Y. Zheng, Small, 13 (6), 1603135, 2017. (Feature as inside front cover story) Mitochondria-Targeting Polydopamine Nanoparticles to Deliver Doxorubicin for Overcoming Drug Resistance, W. Li, Z. Wang, S.-J. Hao, H.He, Y. Wan,C. Zhu, L. Sun, G. Cheng & S. -Y. Zheng, ACS Applied Materials & Interfaces, 9, 16793–16802, 2017.) A Nanostructured Microfluidic Immunoassay Platform for Highly Sensitive Infectious Pathogen Detection, X. Yu, Y. Xia, Y. Tang, W.-L. Zhang, Y.-T. Yeh, H. Lu & S.-Y. Zheng, Small, 13, 1700425, 2017. (Feature as inside front cover story)