叶海峰 - 华东师范大学 - 生命科学学院

个人简介

叶海峰，男，华东师范大学生命科学学院，上海市调控生物学重点实验室研究员，博士生导师。2004年于宁波大学获得理学学士学位，2007年于华东师范大学获得理学硕士学位。2007年8月赴瑞士留学，就读于瑞士苏黎世联邦理工大学（ETH Zurich），攻读生物技术工程博士学位。并于2012年7月获得瑞士苏黎世联邦理工大学，生物系统工程系博士学位。2012年到2013年继续留任原单位进行博士后研究。2013年被授予瑞士苏黎世联邦理工大学最高荣誉奖章：“ETH Silver Medal”。

研究领域

主要从事合成生物学与生物医学工程的研究。主要利用合成生物学理念，人工设计、合成智能基因网络调控系统并用于疾病的诊断与治疗。主要研究内容包括：合成生物学元件及模块的构建；设计合成生物分子信号感应处理元件和细胞自我控制元件；开发智能化诊疗生物器件；以人工合成的基因回路为基础的基因治疗和细胞治疗、开发可调控的智能药物载体系统等，从而为人类疾病的诊断与治疗提供新方法和新策略。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Haifeng Ye, Daoud-El Baba, M., Peng, R.W. & Martin Fussenegger. A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science 332: 1565-68 (2011) Editor’s choice, highlighted by Cell, Nature Medicine, Nature Chemical Biology. Mingqi Xie, Haifeng Ye, Hui Wang, Ghislaine Charpin-El Hamri, Claude Lormeau, Pratik Saxena, Jörg Stelling* and Martin Fussenegger*. β-cell-mimetic designer cells provide closed-loop glycemic control. Science 354:1296-1301 (2016) Highlighted by Nature Reviews Molecular Cell Biology, Molecular Therapy. Haifeng Ye* †, Mingqi Xie†, Shuai Xue, Ghislaine Charpin-El Hamri, Jianli Yin, Henryk Zulewskiand Martin Fussenegger*. Self-adjusting synthetic gene circuit for correcting insulin resistance. Nature Biomedical Engineering 1, 0005, 2016. (co-first and co-corresponding author) Highlighted by Nature Reviews Molecular Cell Biology. Haifeng Ye, Charpin-El Hamri, G., Zwicky, K., Christen, M., Marc Folcher, Martin Fussenegger. Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome. Proc Natl Acad Sci USA 110:141-146 (2013) Interviewed by BBC. Shuai Xue, Jianli Yin, Jiawei Shao, Yuanhuan Yu, Linfeng Yang,Yidan Wang, Mingqi Xie, Martin Fussenegger and Haifeng Ye*, A synthetic biology-inspired therapeutic strategy for targeting and treating hepatogenous diabetes. Molecular Therapy, In press. DOI: http://dx.doi.org/10.1016/j.ymthe.2016.11.008 (corresponding author) Peng Bai,Haifeng Ye,Mingqi Xie,Pratik Saxena,Henryk Zulewski,Ghislaine Charpin-El Hamri,Valentin DjonovandMartin Fussenegger*,A synthetic biology-based device prevents liver injury in mice. Journal of Hepatology 65(1):84-94 (2016) Wang H, Haifeng Ye, Xie M, Daoud El-Baba M, Fussenegger M. Cosmetics-triggered percutaneous remote control of transgene expression in mice. Nucleic Acids Res. 43:e91. (2015) doi:10.1093/nar/gkv326. Mingqi Xie,Haifeng Ye,Hamri GC, Martin Fussenegger,Antagonistic control of a dual-input mammalian gene switch by food additives. Nucleic Acids Res. 42:e166 (2014) Haifeng Ye, Martin Fussenegger.Synthetic therapeutic gene circuits in mammalian cells. FEBS Lett. 588: 2537 (2014) Invited review Haifeng Ye, Aubel, D., Martin Fussenegger, Synthetic mammalian gene circuits for biomedical applications.Curr OpinChem Biol. 17:910-917 (2013) Invited review Haifeng Ye, Jin L, Hu R, Yi Z, Li J, Wu Y, Xi X, Wu Z. Poly(gamma,L-glutamic acid)-cisplatin conjugate effectively inhibits human breast tumor xenografted in nude mice. Biomaterials 27(35):5958-65 (2006)