King, Linda - Oxford Brookes University - Department of Biological and Medical Sciences

个人简介

I am a Professor of Virology and have been Dean of the School of Life Sciences at Oxford Brookes University for the last 8 years until my recent appointment as Associate Dean, Research and Knowledge Transfer for the Faculty of Health and Life Sciences. Following the completion of my doctorate in molecular virology at Oxford University in 1985, my research has focused on various aspects of insect virology with particular emphasis on baculovirus expression systems. I have published more than 90 papers in peer-reviewed journals, reviews and book chapters, and until recently was Insect Virus Editor for The Journal of General Virology. I have spoken at numerous national and international meetings, including The American Society for Virology, The Society for Invertebrate Pathology, Peptalk, Global Protein Summit and Baculovirus Technology. I also played an integral role in the establishment of Oxford Expression Technologies (OET), trading under Oxford Brookes Enterprises Ltd, in 1997 and continue to work as Director and Chair of SAB.

研究领域

The biology and replication of insect baculoviruses in cultured insect cells and in larvae, with a focus on the role of non-essential genes encoding proteins such as P10. chitinase and cathepsin, and the trafficking of virus proteins and particles through insect cells using a range of bioimaging techniques. We are also interested in the exploitation of baculoviruses as gene expression vectors that has led to patenting of a new platform technology ‘flashBAC’ for the production of recombinant viruses and the formation of spin-off company Oxford Expression Technologies Ltd.

近期论文

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Danquah JO, Botchway S, Jeshtadi A, King LA. (2012). Direct interaction of baculovirus capsid proteins VP39 and EXON0 with kinesin-1 in insect cells determined by fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy. Journal of Virology. 86, 844-853. Hitchman RB, Possee RD, King LA. (2012). High-throughput baculovirus expression in insect cells. Methods in Molecular Biology, 824, 609-627. Murgui-Meca, F, Plata-Munoz, JJ, Hitchman, RB, Hughes, D, Fuggle, SV, Friend, PJ & King, LA (2011). Baculoviruses as a delivery system for gene transfer in organ preservation. Transplant International;24(8) DOI:10.1111/j.1432-2277.2011.01252.x King, LA, Danquah, J & Hitchman, RB (2011). Baculoviruses in Medicine: cancer therapies and transplantation. In. Baculoviruses in Medicine, special edition of Journal Invertebrate Pathology (Feb 2011). Possee, RD, Griffiths, CM, Hitchman, RB, Chambers, A, Murguia, F, Danquah, J, Jeshtadi, A & King, LA (2011) Baculoviruses: biology, replication and exploitation. In. Insect Viruses. Ed. Asgari, S & Johnson, K. (Horizon Scientific Press). Hitchman, RB, Possee, RD, Crombie, AT, Chambers, A, Ho, K, Siaterli, E, Lissina, O, Sternard, H, Novy, R, Loomis, K, Bird, LE, Owens, RJ & King, LA (2010) Genetic modification of a baculovirus vector for increased expression in insect cells. Cell Biol. Toxicol. Cell Biol. Toxicol;26(1) DOI:10.1007/s10565-009-9133-y Hitchman, R. B., Possee, R. D., Siaterli, E., Richards, K. S., Clayton, A. J., Birds, L. E., Owens, R. J., Carpentier, D. C. J., King, F. L., Danquah, J. O., Spink, K. G. & King, L. A. (2010). Improved expression of secreted and membrane-targeted proteins in insect cells. Biotechnology and Applied Biochemistry, 56, 85-93.