Orth, Kimberly - UT Southwestern Medical Center

个人简介

Education Undergraduate Texas A & M University (1984) Graduate School University of California-Los Angeles (1986) Graduate School University of Texas Southwestern Med Ctr Dallas (1993) Honors & Awards Earl A. Forsythe Chair in Biomedical Science (2013) ASBMB Young Investigator Award (2012) TAMEST; 2011 Edith & Peter O'Donnell Award in Science (2011) The Welch Foundation Norman Hackerman Award in Chemical Research (2010) Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease (2006) Arnold and Mabel Beckman Young Investigator Award (2003) W.W. Caruth, Jr. Scholar in Biomedical Research, UTSWMC (2001)

研究领域

Research Interest Biochemistry Cellular Signaling Molecular Microbiology

近期论文

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Sreelatha, A., Bennett, T.L., Carpinone, E.M., O’Brien, K.M., Jordan, K.D., Burdette, D.L., Orth, K, & Starai, V.J. The Vibrio effector protein, VopQ, inhibits fusion of V-ATPase containing membranes. (2015) PNAS (In Press). Ham H., Woolery A.R., Tracy C., Stenesen D., Krämer H. & Orth, K. Unfolded protein response-regulated dFic reversibly AMPylates BiP during ER homeostasis. (2014) JBC (In Press). Calder, T., Santos, M.S., Attah, V., Klimko, J., Frernandez, J., Salomon, D., Krachler, A.M., & Orth, K. Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence. (2014) FEMS (In Press). Woolery, A.R., Yu, X., LaBaer, J.& Orth, K. AMPylation of Rho GTPases subverts multiple host signaling processes. (2014) JBC (In Press). Santos, M.S.. & Orth, K. Intracellular Vibrio parahaemolyticus Escapes the Vacuole and Establishes a Replicative Niche in the Cytosol of Epithelial Cells. (2014) mBio (In Press). Yu, X., Woolery, A.R., Luong, P., Hao, Y.H., Grammel, M., Westcott, N., Park, J., Wang, J., Bian, X., Demirkan, G., Hang, H.C., Orth, K. & LaBaer, J. Click chemistry-based detection of global pathogen-host AMPylation on self-assembled human protein microarrays. (2014) Mol & Cell Proteomics (In Press). Calder, T., Kinch, L.N., Fernandez, J., Salomon, D., Grishin, N.V., & Orth, K. Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxin PLoS ONE (In Press). Salomon, D., Klimko, & Orth, K. H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1. (2014) Microbiology (In press). Salomon, D., Kinch, L.N., Trudgian, D.C., Guo, X., Klimko, J.A., Grishin, N.V., Mirzaei, H & Orth, K. Marker for type VI secretion system effectors. PNAS USA (2014) 111(25):9271-6 PMID 24927539. Lewallen,D.M., Sreelatha, A., Dharmarajan, V., Madoux, F., Chase,, F. ,Griffin, P.R., Orth, K., Hoddler, P. & Thompson, P.R. Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation. ACS Chem Biol (2014) 9(2): 433-432 PMC3944102. Sreelatha, A., Orth, K., & Starai, V.J. The pore-forming bacterial effector, VopQ, halts autophagic turnover. Autophagy (2013) 9(12): 2169-70. PMID:24145145 PubMed in process. Salomon D., Guo, Y., Kinch, L.N., Grishin, N.V., Mirzaei, H. & Orth, K. Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides. Nature Communications (2013) 4:2973. Doi:10.1038/n,comms3973. Hawley, C.A., Watson, C., Orth, K. & Krachler, A-M. High-affinity binding of bacterial fibronectin-binding proteins to host cells inhibits critical steps in wound healing. PloS ONE (2013) 8.11:e81216. Sreelatha, A., Bennett,T. L., Zheng, H., Jiang, Q.X., Orth, K.*, & Starai, V.J.* Vibrio VopQ forms a gated outward rectifying channel that disrupts host ion homeostasis. PNAS USA (2013) 110(28):11559-64. Altura, M.A., Heath-Heckman, E.A., Gillette, A. Kremer, A-M, Krachler, A.M. Brennean, c., Ruby, E.G., Orth, K., McFall-Ngai, M.J. (2013) The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells. Environ Microbiol. (2013) Jun 11. doi: 10.1111/1462-2920.12179 (Epub ahead of print). Salomon, D. & Orth, K. What Pathogens Have Taught Us About Posttranslational Modifications (2013) Cell Host Pathogens 14:3 269-279. Krachler, A-M. & Orth, K. Made to stick: Anti-adhesion therapy for bacterial infections as an alternative to conventional antimicrobials. (2013) Microbe 8:286-290. Krachler, A-M. & Orth, K. Targeting the bacteria-host interface: strategies in anti-adhesion therapy (2013) Virulence 4(4): 284-94. Salomon, D. & Orth, K. Lost after translation: post-translational modifications by bacterial type III effectors. (2013) Current Opinions in Microbiology 6(2):213-20. Zhang, L.L & Orth, K. Virulence Determinants for Vibrio parahaemolyticus Infection. Current Opinions in Microbiology (2013) 16(1):70-7.