Grishin, Nikolai - UT Southwestern Medical Center

个人简介

Biography Dr. Grishin is HHMI Investigator and Professor of Biochemistry at UT Southwestern. Born and educated in Russia, he received a Diplom (the Russian equivalent of a master’s degree) in biochemistry from the Moscow State University. His doctoral research in molecular biophysics was done with Margaret Phillips at UT Southwestern. After a postdoctoral year with Eugene Koonin at the National Institutes of Health, he joined the faculty at UT Southwestern. Education Graduate School Moscow State University - Russia (1993) Graduate School University of Texas Southwestern Med Ctr Dallas (1998) Honors & Awards Finn World Travel Award to attend 12th Symposium of the Protein Society (1998) UT Southwestern Graduate School Nominata Award (1998) Department of Pharmacology A.G. Gilman award for excellence in research (1997) GSO Travel Award to attend XVII Congress of Intl. Union of Crystallography (1996)

研究领域

Research Interest We study proteins by means of computational methods

近期论文

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B.Chen, K.Brinkmann, Z.Chen, C.W.Pak, Y.Liao, S.Shi, L.Henry, N.V.Grishin, S.Bogdan, and M.K.Rosen (2014) "The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton." Cell 156(1-2): 195-207; PMID: 24439376 D.Salomon, Y.Guo, L.N.Kinch, N.V.Grishin, K.H.Gardner, and K.Orth (2013) "Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides." Nat Commun. 4: 2973; PMID: 24346350 V.M.Zacharia, P.S.Manzanillo, V.R.Nair, D.K.Marciano, L.N.Kinch, N.V.Grishin, J.C.Cox, and M.U.Shiloh (2013) "cor, a novel carbon monoxide resistance gene, is essential for Mycobacterium tuberculosis pathogenesis." MBio 4(6): e00721-13; PMID: 24255121 J.Pei and N.V.Grishin (2013) "A new family of predicted Krüppel-like factor genes and pseudogenes in placental mammals." PLoS One 8(11): e81109; PMID: 24244731 J.Pei and N.V.Grishin (2013) "PROMALS3D: multiple protein sequence alignment enhanced with evolutionary and three-dimensional structural information." Methods Mol Biol, 1079: 263-271; PMID: 24170408 Y.Wei, Z.Zou, N.Becker, M.Anderson, R.Sumpter, G.Xiao, L.N.Kinch, P.Koduru, C.S.Christudass, R.W.Veltri, N.V.Grishin, M.Peyton, J.Minna, G.Bhagat, and B. Levine (2013) "EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance." Cell 154(6): 1269-1284; PMID: 24034250 R.Ji, Q.Cong, W.Li, and N.V.Grishin (2013) "M2SG: mapping human disease-related genetic variants to protein sequences and genomic loci." Bioinformatics 29(22): 2953-2954; PMID: 24002112 C.He, Y.Wei, K.Sun, B.Li, X.Dong, Z.Zou, Y.Liu, L.N.Kinch, S.Khan, S.Sinha, R.J.Xavier, N.V.Grishin, G.Xiao, E.L.Eskelinen, P.E.Scherer, J.L.Whistler, and B.Levine (2013) "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism." Cell 154(5): 1085-1099; PMID: 23954414 W.Li, L.N.Kinch, and N.V.Grishin (2013) "Pclust: protein network visualization highlighting experimental data." Bioinformatics 29(20): 2647-2648; PMID: 23918248 T.A.Tran, L.N.Kinch, S.Peña-Llopis, L.Kockel, N.V.Grishin, H.Jiang, and J.Brugarolas (2013) "Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1." Mol Cell Biol. 33(19): 3762-3779; PMID: 23878397 L.N.Kinch and N.V.Grishin (2013) "Bioinformatics perspective on rhomboid intramembrane protease evolution and function." Biochim Biophys Acta 1828(12): 2937-2943; PMID: 23845876 M.N.Farley, L.S.Schmidt, J.L.Mester, S.Peña-Llopis, A.Pavia-Jimenez, A.Christie, C.D.Vocke, C.J.Ricketts, J.Peterson, L.Middelton, L.N.Kinch, N.V.Grishin, M.J.Merino, A.R.Metwalli, C.Xing, X.J.Xie, P.L.Dahia, C.Eng, W.M.Linehan, and J.Brugarolas (2013) "A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma." Mol Cancer Res. 11(9): 1061-1071; PMID: 23709298 J.Ning, T.D.Otto, C.Pfander, F.Schwach, M.Brochet, E.Bushell, D.Goulding, M.Sanders, P.A.Lefebvre, J.Pei, N.V.Grishin, G.Vanderlaan, O.Billker, and W.J.Snell (2013) "Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates." Genes Dev. 27(10): 1198-1215; PMID: 23699412 C.Huerta, N.V.Grishin, H.Zhang (2013) "The 'super mutant' of yeast FMN adenylyltransferase enhances the enzyme turnover rate by attenuating product inhibition." Biochemistry 52(21): 3615-3617; PMID: 23663086 S.Shoji-Kawata, R.Sumpter, M.Leveno, C.R.Campbell, Z.Zou, L.N.Kinch, A.D.Wilkins, Q.Sun, K.Pallauf, D.MacDuff, C.Huerta, H.W.Virgin, J.B.Helms, R.Eerland, S.A.Tooze, R.Xavier, D.J.Lenschow, A.Yamamoto, D.King, O.Lichtarge, N.V.Grishin, S.A.Spector, D.V.Kaloyanova, and B.Levine (2013) "Identification of a candidate therapeutic autophagy-inducing peptide." Nature 494(7436): 201-206; PMID: 23364696 W.Li, Q.Cong, L.N.Kinch, and N.V.Grishin (2013) "Seq2Ref: a web server to facilitate functional interpretation." BMC Bioinformatics 14: 30; PMID: 23356573 J.K.Huang, J.Pei, and N.V.Grishin (2013) "Defining and predicting structurally conserved regions in protein superfamilies." Bioinformatics 29(2): 175-181; PMID: 23193223 B-H.Kim, B.Chitturi, and N.V.Grishin (2012) "Self consistency grouping: a stringent clustering method." BMC Bioinformatics 13: S3; PMID: 23320864 F.Quagliarini, Y.Wang, J.Kozlitina, N.V.Grishin, R.Hyde, E.Boerwinkle, D.M.Valenzuela, A.J.Murphy, J.C.Cohen, and H.H.Hobbs (2012) "Atypical angiopoietin-like protein that regulates ANGPTL3." Proc Natl Acad Sci U S A 109(48): 19751-19756; PMID: 23150577 Q.Cong and N.V.Grishin (2012) "MESSA: MEta-Server for protein Sequence Analysis." BMC Biol. 10: 82; PMID: 23031578