Ready, Joseph - UT Southwestern Medical Center

个人简介

Biography I was born in Fayetteville, NC and grew up outside of Philadelphia, PA. As an undergraduate at the University of North Carolina I worked in the laboratories of Paul Kropp and, at the National Institutes of Environmental Health Sciences, Masahiko Negishi. I completed my graduate studies at Harvard University in 2001 under the direction of Eric Jacobsen, studying epoxide ring opening reactions. I then moved to Yale University for a postdoc with John Wood where I focused on total synthesis. I joined the faculty at UT Southwestern in 2003, and my research group currently focuses on natural products synthesis, medicinal chemistry and synthetic methodology. Lab website - http://www.utsouthwestern.edu/labs/ready/ Education Undergraduate University of North Carolina at Chapel Hill (1996), Chemistry Graduate School Harvard University (2001), Chemistry Honors & Awards Alfred P. Sloan Foundation Fellow (2009) Amgen Young Investigator Award (2007) NSF CAREER Award (2006) Southwestern Medical Center Scholar in Biomedical Research (2003) NIH Postdoctoral Fellowship (2001)

研究领域

Discovery and application of new chemical reactions; synthesis of biologically active small molecules

近期论文

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P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage. Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, Yadavalli S, Mirzaei H, Pieper AA, Ready JM, McKnight SL Cell2014 Sep 158 6 1324-34 Pharmacologic Rescue of Motor and Sensory Function by the Neuroprotective Compound P7C3 Following Neonatal Nerve Injury. Kemp SW, Szynkaruk M, Stanoulis KN, Wood MD, Liu EH, Willand MP, Morlock L, Naidoo J, Williams NS, Ready JM, Mangano TJ, Beggs S, Salter MW, Gordon T, Pieper AA, H Borschel G Neuroscience 2014 Oct P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury. Yin TC, Britt JK, De Jesús-Cortés H, Lu Y, Genova RM, Khan MZ, Voorhees JR, Shao J, Katzman AC, Huntington PJ, Wassink C, McDaniel L, Newell EA, Dutca LM, Naidoo J, Cui H, Bassuk AG, Harper MM, McKnight SL, Ready JM, Pieper AACell Rep 2014 Sep 8 6 1731-40 The Ketene-Surrogate Coupling: Catalytic Conversion of Aryl Iodides into Aryl Ketenes through Ynol Ethers. Zhang W, Ready JM Angew. Chem. Int. Ed. Engl. 2014 Jun Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with Improved Druglike Properties. Naidoo J, De Jesus-Cortes H, Huntington P, Estill S, Morlock LK, Starwalt R, Mangano TJ, Williams NS, Pieper AA, Ready JM J. Med. Chem. 2014 Apr P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Pieper AA, McKnight SL, Ready JM Chem Soc Rev 2014 Feb The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM Mol. Psychiatry 2014 Apr In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity. Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK J Mol Biol 2014 May 426 2045-58. Dehydrogenative coupling to enable the enantioselective total synthesis of (-)-simaomicin α. Wang Y, Wang C, Butler JR, Ready JM. Angew Chem Int Ed Engl. 2013 Oct 52 10796-9 On the rapid oxidation of allene-containing phosphines. Cai F, Thangada ND, Pan E, Ready JM. Organometallics 2013 32 5619-22. Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. Kilgore JA, Du X, Melito L, Wei S, Wang C, Chin HG, Posner B, Pradhan S, Ready JM, Williams NS J. Biol. Chem. 2013 May 288 19673-84. Development of scalable synthesis of P7C3-A20, a potent neuroprotective agent. Naidoo J, Bemben CJ, Allwin SR, Lian J, Pieper AA, Ready JM. Tetrahedron Lett 2013 54 4429-4432. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA Proc. Natl. Acad. Sci. U.S.A. 2012 Oct 109 42 17010-5 Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA Proc. Natl. Acad. Sci. U.S.A. 2012 Oct 109 42 17016-21 Cyclocondensation of amino-propargyl silanes. Wang Y, Ready JM Org. Lett. 2012 May 14 9 2308-11 Two-, three-, and four-component coupling to form isoquinolones based on directed metalation. Antczak M, Ready JM. Chem Sci 2012 3 1450-1454. Chiral allene-containing phosphines in asymmetric catalysis. Cai F, Pu X, Qi X, Lynch V, Radha A, Ready JM. J Am Chem Soc. 2011 Nov 133 18066-9. Enantioselective total synthesis of (-)-kibdelone C. Butler JR, Wang C, Bian J, Ready JM. J Am Chem Soc 2011 Jul 133 9956-9. Titanium-mediated oxidative arylation of homoallylic alcohols. Lee KS, Ready JM. Angew Chem Int Ed Engl. 2011 Feb 50 2111-4 Development of proneurogenic, neuroprotective small molecules. MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM. J Am Chem Soc. 2011 Feb 133 1428-37