Nitschke, Jonathan - University of Cambridge

个人简介

Jonathan Nitschke was born in 1973 in Syracuse, New York. Following undergraduate studies (Williams College, MA) and graduate studies (Berkeley, CA) in the U.S., he undertook postdoctoral studies in France, and then started an independent research career at the University of Geneva (Switzerland). The Nitschke group moved to the University of Cambridge (United Kingdom) in 2007.

研究领域

We use chemical self-assembly to create complex structures with targeted functions from simple building blocks. Our work deals with the preparation of complex structures using a process we refer to as subcomponent self-assembly. In this process, simple building blocks (generally aldehydes and amines) come together around templates, which are often metal ions like copper(I) and iron(II), although boron may be used as well. Both covalent (generally C=N) and coordinative (N→Template) bonds are formed during the same overall self-assembly process. Although a great range of products may be possible in theory, and the system may "sample" many different structures during thermodynamic equilibration, only a small subset of all possible product structures are stable with respect to the others. Our central challenge is thus to figure out the rules governing which product structures may be expected to emerge from a complex self-assembling system. These rules may then be used synthetically, to create complex and potentially functional assemblies.

近期论文

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Selective Anion Extraction and Recovery Using a FeII4L4 Cage Dawei Zhang, Tanya K. Ronson, Jesus Mosquera, Alexandre Martinez, and Jonathan R. Nitschke Angew. Chem. Int. Ed., 2018, DOI : 10.1002/anie.201800459 A giant M2L3 metallo-organic helicate based on phthalocyanines as a host for electroactive molecules Ettore Fazio, Cally J. E. Haynes, Gema de la Torre, Jonathan R. Nitschke and Tomás Torres Chem. Commun., 2018, 54, 2651–2654. Quantified structural speciation in CoII6L4 cage systems Felix J. Rizzuto, Marion Kieffer and Jonathan R. Nitschke Chem. Sci., 2018, DOI: 10.1039/C7SC04927G. Covalent post-assembly modification in metallosupramolecular chemistry Derrick A. Roberts, Ben S. Pilgrim and Jonathan R. Nitschke Chem. Soc. Rev., 2017, 47, 626-644. Design Principles for the Optimization of Guest Binding in Aromatic-Paneled FeII4L6 Cages Tanya K. Ronson, Wenjing Meng and Jonathan R. Nitschke J. Am. Chem. Soc., 2017, 139 (28), pp 9698–9707 DOI: 10.1021/jacs.7b05202 Blockable Zn10L15 ion channels via subcomponent self-assembly Cally J. E. Haynes, Jinbo Zhu, Catalin Chimerel, Silvia Hernández-Ainsa, Imogen A. Riddell, Tanya K. Ronson, Ulrich F. Keyser and Jonathan R. Nitschke Angew. Chem. Int. Ed., 2017, DOI : 10.1002/anie.201709544 Signal transduction in a covalent post-assembly modification cascade Ben S. Pilgrim, Derrick A. Roberts, Thorsten G. Lohr, Tanya K. Ronson and Jonathan R. Nitschke Nat. Chem., 2017, 9, 1276-1281. Excitation Energy Delocalization and Transfer to Guests within MII4L6 Cage Frameworks Andrew J. Musser, Prakash P. Neelakandan, Johannes M. Richter, Hirotaka Mori, Richard H. Friend, and Jonathan R. Nitschke J. Am. Chem. Soc., 2017 DOI: 10.1021/jacs.7b06709 Tuning the Redox Properties of Fullerene Clusters within a Metal-Organic Capsule Felix J. Rizzuto, Daniel M. Wood, Tanya K. Ronson, Jonathan R. Nitschke J. Am. Chem. Soc., 2017, 139, 11008–11011. Anion Exchange Renders Hydrophobic Capsules and Cargoes Water-Soluble Dr. Edmundo G. Percástegui, Dr. Jesús Mosquera, Prof. Jonathan R. Nitschke Angew. Chem. Int. Ed., 2017, 56, 9136-9140. Self-assembly of conjugated metallopolymers with tunable length and controlled regiochemistry Jake L. Greenfield, Felix J. Rizzuto, Ieva Goldberga, Jonathan R. Nitschke Angew. Chem. Int. Ed., 2017, 56, 7541-7545. Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage Jesús Mosquera, Bartosz Szyszko, Sarah K. Y. Ho and Jonathan R. Nitschke Nature Communications, 2017, DOI:10.1038/ncomms14882 Anion Binding in Water Drives Structural Adaptation in an Azaphosphatrane-Functionalized FeII4L4 Tetrahedron Dawei Zhang, Tanya K. Ronson, Jesús Mosquera, Alexandre Martinez, Laure Guy and Jonathan R. Nitschke. J. Am. Chem. Soc., 2017, 139, 6574-6577. Stereochemical plasticity modulates cooperative binding in a CoII12L6 cuboctahedron Felix J. Rizzuto and Jonathan R. Nitschke Nature Chemistry, 2017, DOI:10.1038/nchem.2758 Subcomponent Exchange Transforms an FeII4L4 Cage from High- to Low-Spin, Switching Guest Release in a Two-Cage System Anna J. McConnell, Catherine M. Aitchison, Angela B. Grommet, and Jonathan R. Nitschke J. Am. Chem. Soc., 2017, 139, 6294–6297 An Octanuclear Metallosupramolecular Cage Designed To Exhibit Spin-Crossover Behavior Niklas Struch, Christoph Bannwarth, Tanya K. Ronson, Yvonne Lorenz, Bernd Mienert, Norbert Wagner, Marianne Engeser, Eckhard Bill, Rakesh Puttreddy, Kari Rissanen, Johannes Beck, Stefan Grimme, Jonathan R. Nitschke, and Arne Ltzen Angew. Chem. Int. Ed., 2017, 56, 4930-4935 Directed Phase Transfer of an FeII4L4 Cage and Encapsulated Cargo Angela Grommet, Jonathan R. Nitschke J. Am. Chem. Soc., 2017, 139, 2176-2179 Separation and Selective Formation of Fullerene Adducts within an MII8L6 Cage Wolfgang Brenner, Tanya K. Ronson, and Jonathan R. Nitschke J. Am. Chem. Soc., 2017, 139, 75–78 Anion Recognition as a Supramolecular Switch of Cell Internalization Jéssica Rodríguez, Jesús Mosquera, José R. Couceiro, Jonathan R. Nitschke , M. Eugenio Vázquez, and José L. Mascareñas J. Am. Chem. Soc., 2017,139, 55–58 Pathway-Dependent Post-assembly Modification of an Anthracene-Edged MII4L6 Tetrahedron Tanya K Ronson, Ben S. Pilgrim, and Jonathan R. Nitschke J. Am. Chem. Soc. 2016, 138, 10417-10420.