个人简介

Dr Matthew Fuchter obtained his first class honours degree (MSci) from the University of Bristol in 2002, where he was awarded the Richard N. Dixon prize as well as an undergraduate scholarship and several faculty commendations. In January 2006 he completed his PhD research entitled “Synthetic Studies on Porphyrazines: Biological Applications and New Preparative Methods” under the supervision of Professor A. G. M. Barrett, FRS FMedSci at Imperial College London. Within the group of Professor Barrett, he was promoted to the position of Group Leader, which involved numerous supervisory and organisational responsibilities. Following a short spell as a Research Associate at Imperial College, Dr Fuchter was appointed as a CSIRO Research Fellow at the Commonwealth Scientific and Industrial Research Organisation, Australia as well as a visiting fellow at the University of Melbourne, where he worked with Professor A. B Holmes, FRS. From August 2007 he was the RCUK Academic Fellow in Cancer Medicinal Chemistry at the School of Pharmacy, University of London, and in July 2008 he was appointed as a Lecturer in Synthetic and Medicinal Chemistry at Imperial College London. He was promoted to Senior Lecturer in July 2012. In 2014 he was awarded the RSC Harrison-Meldola Memorial Prize, as well as being admitted to the Royal Society of Chemistry as a Fellow.

研究领域

Synthesis

The Fuchter Group use expertise in chemical synthesis to impact molecular science in chemistry, biology and materials

近期论文

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"Chiroptical studies on brevianamide B: Vibrational and Electronic Circular Dichroism confronted" Bultinck, P.; Cherblanc, F. L.; Fuchter, M. J.*; Herrebout, W. A.; Lo, Y. –L.; Rzepa, H. S.*; Siligardi, G.; Weimar, M. J. Org. Chem. 2015, in press. DOI "Histone methyltransferase inhibitors: orally bioavailable, fast acting molecules with activity against different human malaria species" Malmquist, N. A.*; Sundriyal, S.; Caron, J.; Chen, P.; Witkowski, B.; Menard, D.; Suwanarusk, R.; Renia, L.; Nosten, F.; Jiménez-Díaz, M. B.; Angulo-Barturen, I.; Martínez, M. S.; Ferrer, S.; Sanz, L. M.; Gamo, F. J.; Wittlin, S.; Duffy, S.; Avery, V. M.; Ruecker, A.; Delves, M. J.; Sinden, R. E.; Fuchter, M. J.; Scherf, A.* Antimicrob. Agents Chemother. 2015, 59, 950. DOI "The Discovery of a Highly Selective 5,6,7,8- Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model" Di Fruscia, P.; Zacharioudakis, E.; Liu, C.; Moniot, S.; Laohasinnarong, S.; Khongkow, M.; Harrison, I. F.; Koltsida, K.; Reynolds, C. R.; Schmidtkunz, K.; Jung, M.; Chapman, K. L.; Steegborn, C.; Dexter, D. T.; Sternberg, M. J. E.; Lam, E. W.-F.; Fuchter, M. J.* ChemMedChem 2015, 10, 69. DOI "Non-Metal Catalysed Hydrogenation of Carbonyl Compounds" Scott, D. J.; Fuchter, M. J.; Ashley, A. E.* J. Am. Chem. Soc. 2014, 136, 15813. DOI Highlighted in Chemical and Engineering news DOI "Identification of 2,4-Diamino-6,7-dimethoxyquinoline derivatives as G9a Inhibitors" Srimongkolpithak, N.; Sundriyal, S.; Lu, F.; Vedadi, M.; Fuchter, M. J.* Med. Chem. Commun. 2014, 5, 1821. DOI - Invited Submission - Epigenetics special issue, cover article "Metal-Free Hydrogenation Catalyzed by an Air-Stable Borane: Use of Solvent as a Frustrated Lewis Base" Scott, D. J.; Fuchter, M. J.; Ashley, A. E.* Angew. Chem. Int. Ed 2014, 53, 10218. DOI Angew. Hot paper "Arylazopyrazoles: Azoheteroarene photoswitches offering quantitative isomerization and long thermal half-lives" Weston, C. E.; Richardson, R. D.; Haycock, P. R.; White, A. J. P.; Fuchter, M. J.* J. Am. Chem. Soc. 2014, 136, 11878. DOI "Calcium-mediated stereoselective reduction of α,β-epoxy ketones" Forkel, N. V.; Henderson, D. A.; Fuchter, M. J.* Tetrahedron Lett. 2014, 55, 5511. DOI "Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-Stage Antimalarial Compounds" Sundriyal, S.; Malmquist, N. A.; Caron, J.; Blundell, S.; Liu, F.; Chen, X.; Srimongkolpithak, N.; Jin, J.; Charman, S. A.; Scherf, A.; Fuchter, M. J.* ChemMedChem 2014, 9, 2360. DOI "Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors" Meyners,C.; Baud, M. G. J.; Fuchter, M. J.; Meyer-Almes, F. -J.* Anal. Biochem. 2014, 460, 39. DOI "PROFILE: Early Excellence in Physical Organic Chemistry" Fuchter, M. J. J. Phys. Org. Chem. 2014, 27, 545. DOI - Investigator highlight of M. J. Fuchter "Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures" Dembélé, L.; Franetich, J. –F.; Lorthiois, A.; Gego, A.; Zeeman, A. M.; Kocken, C. H. M.; Le Grand, R.; Dereuddre-Bosquet, N.; van Gemert, G. –J.; Sauerwein, R.; Vaillant, J. –C.; Hannoun, L.; Fuchter, M. J.; Diagana, T.; Malmquist, N. A.; Scherf, A.; Snounou, G.*; Mazier, D. Nature Med. 2014, 20, 307. DOI Highlighted in Nature Medicine DOI "Gold(I) mediated rearrangement of [7]-helicene to give a benzo[cd]pyrenium cation embedded in a chiral framework" Berger, R. J. F.; Fuchter, M. J.*;
Krossing, I.; Rzepa, H. S.; Schaefer, J.; Scherer, H. Chem. Commun. 2014, 50, 5251. DOI - Invited Submission - 2014 Emerging Investigators issue "Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes" Meyners, C.; Baud, M. G. J.; Fuchter, M. J.; Meyer-Almes, F. -J.* J. Mol. Recognit. 2014, 27, 160. DOI