个人简介

K.P. Chaired Professor, Zhejiang University 2009-Present Professor, North Carolina State University 1997-Present EMBO Fellow, Ecole Polytechnique, Palaiseau, France 1992-1994 Los Alamos Director's Fellow, Los Alamos, New Mexico 1994-1997 Stanford University, Stanford, California Ph.D. 1992 Peace Corps Volunteer Teacher, Torongo, Kenya 1982-1985 University of California, Berkeley B.S. 1982

研究领域

Physical Chemistry

The research goals of the Franzen group involve the discovery of new ways to think about problems. This is not defined as simply development of a technique or a theory. For example, in the area of plasmonics we have pioneered the use of conducting metal oxides. Some may ask whether conducting metal oxides can rival gold and silver in their sensitivity. We are more interested in finding the possibilities simply because these materials have never been expored before in the field of surface plasmon resonance. We certainly hope that practical uses will arise, but at the moment we are discovering many new aspects of surface plasmon resonance that contribute fundamentally to the field. In the study of dehaloperoxidase, we have been led to inquire in a fundamental way what the role is of radicals in enzymology. Are radical friend or foe? Do they aid in the transfer of electrons? Do they facilitate the formation of product or do they lead to unproductive side reactions. Through our recent discovery that the radical pathway in a protein (DHP) is moduclated by the position of a single amino acid we now see an example of a radical switch. Is the function related to protection of the protein? We are exploring these and related questions that have fundamental interest in the chemistry of the immune system, biormediation in the environment, and oxidative catalysis for the synthesis of drugs, vitamins and other molecules of interest.

近期论文

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September 10, 2010, Publication of Biophysical Journal article showing the two-site competitive inhibition. September, 15 2009, Publication of our paper in Optics Letters showing the first hybrid plasmon. We layered gold nanoparticle layers onto indium tin oxide to makes a plasmonic material composed of two different conducting layers. The physics of this substrate has ramifications for how we use plasmonic materials in capture of light for solar energy as well as sensing applications. January, 2008, Publication of our paper in Chemical Communications showing the opening-closing transition of the plant virus, RCNMV (Red clover necrotic mosaic virus). This process was demonstrated to permit loading of nearly 1000 molecules of the chemotherapy agent doxorubicin. The loading density is higher than the commercial liposome preparation known as Doxil(TM).