研究领域
1.生物大分子的识别以及与配体相互作用机制研究
2.纳米界面生物分子作用机制研究
3.基于纳米材料的生物传感器的自组装机制及应用研究
近期论文
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Gongke Wang, Yanfang Lu, Changling Yan, Yan Lu. DNA-Functionalization Gold Nanoparticles based Fluorescence sensor for sensitive detection of Hg2+ in aqueous solution. Sensors and Actuators B: Chemical, 2015, 211: 1–6.
Gongke Wang, Ye Chen, Changling Yan, Yan Lu. Study on the interaction between gold nanoparticles and papain by spectroscopic methods. Journal of Luminescence, 2015, 157: 229–234.
Gongke Wang, Changling Yan, Yan Lu. Exploring DNA binding properties and biological activities of dihydropyrimidinones derivatives. Colloids and Surfaces B: Biointerfaces, 2013, 106, 28– 36.
Gongke Wang, Hongwei Wu, Dongchao Wang, Changling Yan, Yan Lu. Exploring the binding mechanism of phosphoramidate derivative with DNA: Spectroscopy, calorimetry and modeling. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013, 104, 492–496.
Gongke Wang, Xiangrong Li, Yaping Gou, Yuhan Chen, Changling Yan, Yan Lu. DNA binding properties and biological evaluation of dihydropyrimidinones derivatives as potential antitumor agents. Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy, 2013, 114: 214-219.
Gongke Wang, Changling Yan, Dongchao Wang, Yan Lu. Specific binding of a dihydropyrimidinone derivative with DNA: Spectroscopic, calorimetric and modeling investigations. Journal of Luminescence, 2012, 132: 1656–1662.
Gongke Wang, Xiang Li, Xuelian Ding, Dongchao Wang, Changling Yan, Yan Lu. Exploring the mechanism of interaction between 5-(Ethoxycarbonyl)-6-methyl-4-(4-methoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one and human serum albumin: spectroscopic, calorimetric and molecular modeling studies. Journal of Pharmaceutical and Biomedical Analysis, 2011, 55: 1223–1226.
Gongke Wang, Dongchao Wang, Xiang Li，Yan Lu. Exploring the binding mechanism of dihydropyrimidinones to human serum albumin: Spectroscopic and molecular modeling techniques. Colloids and Surfaces B: Biointerfaces, 2011, 84: 272–279.
Gongke Wang, Lixia Wang, Xiaoxiao Hao, Wen Tang, Yunlai Wang, Yan Lu. Binding of quercetin to Lysozyme as probed by spectroscopic analysis and molecular simulation. Journal of Fluorescence, 2011, 21: 1879–1886.
Gongke Wang, Wen Tang, Xiaoxiao Hao, Changling Yan, Yan Lu. Binding mechanism of halide Ions to bovine serum albumin and hemoglobin: investigated by Ion selective-electrode. Journal of Biophysical Chemistry, 2011, 2(3): 194–201.
Yan Lu, Gongke Wang, Xiumin Lu, Juan Lv, Meihua Xu, Weiwei Zhang. Molecular mechanism of interaction between norfloxacin and trypsin studied by molecular spectroscopy and modeling. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2010, 75: 261–266.
Yan Lu, Gongke Wang, Wen Tang, Xiaoxiao Hao, Meihua Xu, Xiang Li. Study on the interaction of amino phosphine ester derivatives with DNA by spectroscopy, modeling and calorimetry. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2011, 82: 247–252.
Xiangrong Li, Gongke Wang, Dejun Chen, Yan Lu*, Binding of ascorbic acid and α-tocopherol to bovine serum albumin: A comparative study, Molecular bioSystems, 2014, 10, 326-337.
Xiang Li, GongKe Wang, Xuelian Ding, Yuhan Chen, Yaping Gou, Yan Lu. A “turn-on” fluorescent sensor for Pb2+ based on graphene oxide and G-quadruplex DNA. Physical Chemistry Chemical Physics, 2013, 15: 12800-12804.
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