Lu, Yi - University of Illinois at Urbana-Champaign

个人简介

Dr. Yi Lu graduated with a B.S. in Chemistry from Peking University in 1986 and received his Ph.D. degree from UCLA in 1992 under Dr. Joan S. Valentine. After two years of postdoctoral research in the group of Dr. Harry B. Gray at the Caltech, Dr. Lu started his own independent career in the Department of Chemistry at the University of Illinois at Urbana-Champaign in 1994. He is now Jay and Ann Schenck Professor in the Departments of Chemistry, Biochemistry, Materials Science and Engineering and Bioengineering. He is also a member of the Center for Biophysics and Computational Biology and Beckman Institute for Advanced Science and Technology. His research interests lie at the interface between chemistry and biology, and his group is developing new chemical approaches to provide deeper insight into biological systems. At the same time, they take advantage of recently developed biological tools to advance many areas in chemistry. Specific areas of current interests include a) design and engineering of functional metalloproteins as environmentally benign catalysis in renewable energy generation and pharmaceuticals; b) developing a fundamental understanding of DNAzymes and their applications in environmental monitoring, medical diagnostics, and targeted drug delivery; and c) employing principles from biology for directed assembly of nanomaterials and developing their applications in photonics and sensing. Dr. Lu has received numerous research and teaching awards, including the Royal Society of Chemistry Applied Inorganic Chemistry Award (2015), Fellow of the Royal Society of Chemistry (FRSC, 2015), Fellow of the American Association for the Advancement of Science (2007), Early Career Award from the Society of Biological Inorganic Chemistry (2007), Howard Hughes Medical Institute Professor Award (2002), Camile Dreyfus Teacher-Scholar Award (1999), Alfred P. Sloan Research Fellowship (1998), Research Corporation Cottrell Scholars Award (1997), and Beckman Young Investigators Award (1996). Dr. Lu is also at the forefront in innovation in teaching (see Science, 318, 1872-1873 (2007) and http://atlas.scs.uiuc.edu/chem199l/). Research in his lab has resulted in more than twenty US and international patents as well as successful products in environmental monitoring (www.ANDalyze.com) and medical diagnostics (www.GlucoSentient.com). Dr. Lu has been ranked among the world’s most influential researchers from 2015-2018.

研究领域

The Lu group’s interests lie at the interface between chemistry and biology. We are developing innovative chemical approaches to provide deeper insight into biological structures and functions. We are also taking advantage of recently developed biological tools to advance many areas in chemistry, such as inorganic chemistry, chemical biology, analytical chemistry, and materials chemistry. We strive to make significant contributions in three principal areas of research: 1. Biosynthetic Inorganic Chemistry Synthesis and study of structural and functional mimics of metalloenzymes and their applications as biocatalysts in renewable energy generation and small-molecule activation and transformation. 2. DNAzyme and Aptamer-Based Sensing and Imaging Agents In vitro selection of DNAzymes/aptamers and development of highly sensitive and selective sensors and imaging agents for metal ions and small-molecule targets with applications in environmental monitoring, food safety, and medical diagnostics and imaging. 3. Functional DNA Nanotechnology Using DNA for encoded synthesis and directed assembly of nanomaterials and their applications as theranostic agents for early detection of diseases such as cancers and targeted drug delivery.

近期论文

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Changhe Ouyang, Songbai Zhang, Chang Xue, Xin Yu, Huo Xu, Zhenmeng Wang, Yi Lu, Zai-Sheng Wu "Precision-Guided Missile-Like DNA Nanostructure Containing Warhead and Guidance Control for Aptamer-Based Targeted Drug Delivery into Cancer Cells in Vitro and in Vivo"J. Am. Chem. Soc. (in press) (2020) [PDF] [doi] [+] Yugang Bai, Hang Xing, Yunhao Bai, Li Huey Tan, Kevin Hwang, Ji Li, Yi Lu, Steven C. Zimmerman "Independent Control over Size, Valence, and Elemental Composition in the Synthesis of DNA-Nanoparticle Conjugates" Chem. Sci. (in press) (2020) [PDF] [doi] Ying Xiong, Jingjing Zhang, Zhenglin Yang, Quanbing Mou, Yuan Ma, Yonghua Xiong, Yi Lu "DNA Regulated CRISPR-Cas12a Sensors for Point-of-Care Diagnostics of Non-Nucleic Acid Targets"J. Am. Chem. Soc. 142, 207-213 (2020) [PDF] [doi] [+] JingJing Zhang, Tian Lan, Yi Lu "Translating in vitro Diagnostics from Centralized Laboratories to Point-of-Cares using Commercially-Available Handheld Meters"Trends Anal. Chem. (in press) (2019) [doi] [+] Samantha G. Zambuto, Julio F. Serrano, Avery C. Vilbert, Yi Lu, Brendan Harley, Sara Pedron "Response of neuroglia to hypoxia-induced oxidative stress using enzymatically crosslinked hydrogels"MRS Communications (in press) (2019) [doi] Ana Sol Peinetti, Ryan Lake, Yi Lu "Functional DNA Sensors for Heavy Metal Ions and Microbial Contaminants in Water" in Water Sensors (Junhong Chen and Matthew Tirrell eds.), World Scientific Publishing Company (in press) (2019) Shanni Hong, Xiaoting Zhang, Ryan J. Lake, Gregory T. Pawel, Zijian Guo, Renjun Pei and Yi Lu "Photo-regulated aptamer sensor for spatiotemporally controlled monitoring of ATP in mitochondria of living cells" Chem. Sci. (in press) (2019) [PDF] [doi] Mengyi Xiong, Zhenglin Yang, Ryan J. Lake, Junjie Li, Shanni Hong, Huanhuan Fan, Xiao-Bing Zhang, Yi Lu "DNAzyme-Mediated Genetically Encoded Sensors for Ratiometric Imaging of Metal Ions in Living Cells" Angew. Chemie Int. Ed. (in press) (2019) [PDF] [doi] Chang Xue, Songbai Zhang, Congcong Li, Xin Yu, Changhe Ouyang, Yi Lu, Zai-Sheng Wu "Y-shaped backbone-rigidified triangular DNA scaffold-directed stepwise movement of DNAzyme walker for sensitive microRNA imaging within living cells" Anal. Chem. 91, 15678-15685 (2019) [PDF] [doi] [+] Ryan J. Lake, Zhenglin Yang, JingJing Zhang, Yi Lu "DNAzymes as Activity-Based Sensors for Metal Ions: Recent Applications, Demonstrated Advantages, Current Challenges, and Future Directions" Acc. Chem. Res. 52, 3275-3286 (2019) [PDF] [doi] [+] Wentao Xu, Wanchong He, Zaihui Du, Liye Zhu, Kunlun Huang, Yi Lu, Yunbo Luo "Functional Nucleic Acids-Nanomaterials: Development, Properties, and Applications" Angew Chemie Int. Ed. (in press) (2019) [PDF] [doi] Noor Zaouri, Zhengfang Cui, Ana Sol Peinetti, Yi Lu, Pei-Ying Hong "DNAzyme-based biosensor as a rapid and accurate verification tool to complement simultaneous enzyme-based media for E. coli detection"Environ. Sci. Water Res. & Tech 5, 2260-2268 (2019) [PDF] [doi] Lin Xia, Ming-Jie Han, Lu Zhou, Aiping Huang, Zhaoya Yang, Tianyuan Wang, Fahui Li, Lu Yu, Changlin Tian, Zhongsheng Zang, Qing-Zheng Yang, Chenli Liu, Wenxu Hong, Yi Lu, Lital Alfonta, Jiangyun Wang "S-Click Reaction for Isotropic Orientation of Oxidases on Electrodes to Promote Electron Transfer at Low Potentials" Angew Chemie Int. Ed. 58, 16480-16484 (2019) [PDF] [doi] Yao Lin, Zhenglin Yang, Ryan J. Lake, Chengbin Zheng, Yi Lu "Enzyme-Mediated Endogenous and Bioorthogonal Control of a DNAzyme Fluorescent Sensor for Imaging Metal Ions in Living Cells" Angew Chemie Int. Ed. 58, 17061-17067 (2019) [PDF] [doi] Taylor D. Canady, Nantao Li, Lucas D. Smith, Yi Lu, Manish Kohli, Andrew M. Smith, Brian T. Cunningham "Digital Resolution Detection of miRNA with Single Base Selectivity by Photonic Resonator Absorption Microscopy"Proc. Natl. Acd. Sci. USA 116, 19362-19367 (2019) [PDF] [doi] Lele Li, Hang Xing, Jingjing Zhang, Yi Lu "Functional DNA Molecules Enable Selective and Stimuli-Responsive Nanoparticles for Biomedical Applications" Acc. Chem. Res. (special issue “Nanomedicine and Beyond”) 52, 2415-2426 (2019) [PDF] [doi] [+] Wenjing Wang, Sha Yu, Shan Huang, Sai Bi, Heyou Han, Jian-Rong Zhang, Yi Lu, Jun-Jie Zhu "Bioapplications of DNA nanotechnology at the solid–liquid interface" Chem. Soc. Rev. 48, 4892-4920 (2019) [PDF] [doi] [+] Kevin Hwang, Quanbing Mou, Ryan J. Lake, Mengyi Xiong, Brandalynn Holland, Yi Lu "Metal-Dependent DNAzymes for the Quantitative Detection of Metal Ions in Living Cells: Recent Progress, Current Challenges, and Latest Results on FRET Ratiometric Sensors" inorg. Chem. 58, 13696-13708 (2019) [PDF] [doi] [+] Jinqiong Xu, Xiujuan Qiao, Jingjing Zhang, Ni Cheng, Qinglin Sheng, Jianbin Zheng, Wei Cao, Tianli Yue, Yi Lu "Point-of-care monitoring of intracellular glutathione and serum triglyceride levels using a versatile personal glucose meter" Anal. Methods 11, 1849-1856 (2019) [PDF] [doi] [+] Ambika Bhagi-Damodaran, Yi Lu "The Periodic Table’s Impact on Bio-inorganic Chemistry and Biology’s Selective use of Metal Ions" in Structures and Bonding (Special Issue on A Celebration of 150 years of the Periodic Table), in press (2019) [doi]