研究领域
微量活体样品分离与成像分析
1.高速高效毛细管与芯片电泳（CE）
2.表面等离子体共振成像(SPRi)
3.生物质谱与应用（bMS）
毛细管电泳是本组主要也是最早展开研究的微量高效高速分析方法，研究内容涉及仪器研制、活细胞测定、蛋白分析、天然草药分析等。新近的研究包括规则分离介质的合成及组装、芯片电泳、超高速分离、基于芯片的化学合成、塑料及玻璃芯片的快速制备等。
主要项目:1)赤霉素测定,2)色谱分离新介质,3)手性分离
表面等离子体共振传感与成像是本组的另一重要研究，目标是发展免标记的高通量生物识别与分析方法，内容包括实验装置及商品样机研制、高密度可寻址识别点阵传感芯片制作、微点定性与定量测定、蛋白/糖/DNA的识别筛查、信号增敏方法等。
主要项目：1)SPR耦合新结构及装置研制，2)高通量免标记识别与筛选分析方法，3)肿瘤标志物分析，4）赤霉素分析，5）联用方案
质谱是本组最晚开始的研究，目的在于寻找进行生物分子无损鉴定的新方法，焦点是发展生物分子质量准确测定的新思路和新方法。目前有GC-MS、LC-MS的研究是发展高效离子源和高可靠校标新技术。
主要项目：1)赤霉素鉴定，2)脑脊液活性成分鉴定，3)质量校标新方法
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Tao Liao, Zhengpeng Guo,Jincheng Li, Meirong Liu, Yi Chen*, One-step packing of anti-voltage photonic crystals into microfluidic channels for ultra-fast separation of amino acids and peptides, Lab Chip, 2013, 13, 706–713.
Xun Yuan, Yi Chen*, Visual determination of Cu2+ through copper-catalysed in situ formation of Ag nanoparticles, Analyst, 2012, 137, 4516–4523.
Lipo Ma, Bin Xin, Yi Chen*, Direct mass spectrometric detection of trace explosives in soil samples, Analyst , 2012, 137, 1730–1736 .
Kai Liang, Yi Chen*, Elegant Chemistry to Directly Anchor Intact Saccharides on Solid Surfaces Used for the Fabrication of Bioactivity-Conserved Saccharide Microarrays, Bioconjugate Chem. 2012, 23, 1300-1308.
Jincheng Li, Jian'an Liu, Yi Chen*, Matrix-assisted laser ablation production of gold cluster ions from Au-coated photonic crystals, J. Mass. Spectrom. 2012, 47, 620–626.
Yiming Zhang, Xun Yuan, Yuan Wang, Yi Chen*, One-pot photochemical synthesis of graphene composites uniformly deposited with silver nanoparticles and their high catalytic activity towards the reduction of 2-nitroaniline, J. Mater. Chem. 2012, 22, 7245–7251.
Jun Chen , Yi Chen*, Jiying Xu, Yiming Zhang, Tao Liao, Post-experimental denoising and background subtraction of surface plasmon resonance images for better quantification, Chemometrics and Intelligent Laboratory Systems , 2012,114, 56–63.
Lijuan Song, Zhenpeng Guo, Yi Chen*, Separation and determination of chiral composition in penicillamine tablets by capillary electrophoresis in a broad pH range, Electrophoresis , 2012, 33, 2056–2063.
Stephen A. Teale, Jacob D. Wickham, Feiping Zhang, Jun Su, Yi Chen,Wei Xiao, Lawrence M. Hanks, Jocelyn G. Millar, A Male-Produced Aggregation Pheromone of Monochamus alternatus (Coleoptera: Cerambycidae), a Major Vector of Pine Wood Nematode, J. Econ. Entomol., 2011,104, 1592-1598.
Huibin Wang, Yiming Zhang, Xun Yuan, Yi Chen*, and Mingdi Yan*, A Universal Protocol for Photochemical Covalent Immobilization of Intact Carbohydrates for the Preparation of Carbohydrate Microarrays, Bioconjugate Chem. , 2011 , 22(1), 26-32
Lijuan Song, Zhenpeng Guo, Yi Chen*, One-pot labeling-based capillary zone electrophoresis for separation of amino acid mixture and assay of biofluids, Anal. Chim. Acta , 2011 , 703(2), 257-263.
Su-Hua Yang, Yi-Ming Zhang, Tao Liao, Zhen-Peng Guo, Yi Chen*, Electromigration diffusivity spectrometry: A way for simultaneous determination of diffusion coefficients from mixed samples, Electrophoresis , 2010, 31, 2949-2956.
Shu Zhang, Jian-An Liu, Yi Chen*, Shao-Xiang Xiong, Guang-Hui Wang, Jun Chen, Guo-Qiang Yang, A novel strategy for MALDI-TOF MS analysis of small molecules, J. Am. Soc. Mass Spectrom. , 2010, 21, 154-160.
Hao-Wen Huang*, Shao-Wen Huang, Xuan-Yong Liu, Yun-Long Zeng,Xian-Yong Yu, Bo Liao, Yi Chen**, Label-free optical biosensors based on Au 2 S-coated gold nanorods, Biosensors and Bioelectronics , 2009 , 24 , 3025-3029 .
Ming-Yi Xie, Hai Wang, Yi Chen*, Insight into the interaction of E. coli with gentamycin by ultrafast electrophoresis achieved within the microscopic visual field, Electrophoresis , 2009, 30 , 3884-3890.
Xiao-Yu Wang, Yi Chen*, Determination of aromatic amines in food products and composite food packaging bags by capillary electrophoresis coupled with transient isotachophoretic stacking, Journal of Chromatography A , 2009, 1216, 7324 - 7328.
Yi Chen*, Zhenpeng Guo, Xiaoyu Wang, Changgui Qiu, Sample preparation, J. Chromatogr. A, 2008, 1184, 191-219.
Li Qi, Yi Chen*, Mingyi Xie, Zhenpeng Guo, Xiaoyu Wang. Separation of dansylated amino acid enantiomers by chiral ligand-exchange CE with a zinc(II) L-arginine complex as the selecting system, Electrophoresis, 2008, 29, 4277-4283.
Wei Liu, Yi Chen*, Mingdi Yan, Surface plasmon resonance imaging of limited glycoprotein samples. Analyst, 2008, 133, 1268-1273
Zhiqiang Han, Li Qi, Gangyi Shen, Wei Liu and Yi Chen*. Determination of chromium (VI) by surface plasmon field-enhanced resonance light-scattering. Analytical Chemistry, 2007, 79: 5862-5968.
京公网安备 11010802027423号