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研究领域

有机化学(药物与材料)、生物医学高分子材料 1.功能导向新药用材料的可控、高效、绿色设计合成理论和方法 2.基于天然产物(环状多肽和小分子活性组分)的化学生物学研究 3.生物高分子材料(蛋白质和多糖)的化学修饰及其功能调控 4.纳米生物医学材料的空间仿生合成、与细胞相互作用及调控规律。

近期论文

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Samanta S.,Qin C.G.,Lough A.J., Woolley G.A*. (2012). Bi-directional photo-control of peptide conformation with a bridged azobenzene derivative.Angew. Chem. Int. Ed.51 (26):6452-6455. Samanta S.,Qin C.G.,Lough A.J., Woolley G.A*. (2012). Bi-directional photo-control of peptide conformation with a bridged azobenzene derivative.Angew. Chem.124 (26):6558-6561. Qin,C.G.*,Li, Y., Niu, W.N., et al. (2011). Composition analysis and structure identification of anthocyanins in fruit of waxberry.Czech Journal of Food Science29(2): 171-180. Qin,C.G.*,Xu, C.L., Zhang, R.J., et al. (2010). On-resin cyclization and antimicrobial activity of Laterocidin and its analogues.Tetrahedron Letters51(9):1257-1261. Xu, C.L.,Qin, C.G.*,Zhang, R.J., et al. (2010). Solid-phase synthesis and antibiotic activities of cyclodecapeptides on the scaffold of naturally occurring Laterocidin.Bioorganic & Medicinal Chemistry Letters20 (1):164-167. Qin,C.G.*,Li, Y., Niu, W.N., et al. (2010). Analysis and characterisation of anthocyanins in mulberry fruit.Czech Journal of Food Science28(2): 117-126. Qin, C.G.*, Li, Y., Zhang, R.J., et al.(2009). Separation and elucidation of anthocyanins in fruit of mockstrawberry (Duchesnea indica Focke).Natural Product Research23(17): 1589-1598. Qin,C.G.*,Ding, Y., Hang, K.X., et al. (2008).Protective effect ofMisgurnus anguillicaudatuspolysaccharide on immunological liver injury in mice.International Immunopharmacology8(5):607-612. Ding, Y.,Qin,C.G.*,Guo, Z.H., et al.(2007).Solid-phase total synthesis and antimicrobial activities of Loloatins A-D.Chemistry & Biodiversity4(12):2827-2834. Ding, Y.,Qin,C.G.*,Niu, W.N., et al.(2007).Solid-phase synthesis and self-assembly formation of Tyrocidines.Polish Journal of Chemistry,81(9):1577–1585. Qin, C.G.,Wavreille, A.-S., Pei, D.H. (2005) Alternative mode of binding to phosphotyrosyl peptides by Src Homology-2 domains.Biochemistry44(36):12196-12202. Qin, C.G.,Bu, X.Z., Zhong, X.F., et al. (2004). Optimization of antibacterial cyclic decapeptides.Journal of Combinatorial Chemistry6 (3): 398-406. Qin, C.G.,Zhong, X.F., Ng, N.L., et al. (2004). Facile solid-phase synthesis of cyclic decapeptide antibiotic Streptocidins A-D.Tetrahedron Letters45 (1): 217-220. Qin, C.G.,Zhong, X.F., Bu, X.Z., Guo, Z.H. (2003). Dissociation of antibacterial and hemolytic activities of an amphipathic peptide antibiotc.Journal of Medicinal Chemistry46 (23): 4830-4833. Qin, C.G.,Bu, X.Z., Wu, X.M., Guo, Z.H. (2003). A chemical approach to generate molecular diversity based on the scaffold of cyclic decapeptide antibiotic Tyrocidine A.Journal of Combinatorial Chemistry5 (4): 353-355. Qin, C.G.,Huang, K.X., Xu, H.B. (2002).Isolation and characterization of a novel polysaccharide from the mucus of the loach, Misgurnus anguillicaudatus.Carbohydrate Polymers49 (3): 367-371. Qin, C.G.,Huang, K.X., Xu, H.B. (2002).Protective effect of polysaccharide from the loach on the in vitro and in vivo peroxidative damage of hepatocyte.Journal of Nutrition Biochemistry13 (10): 592-597.

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