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功能高分子材料,高分子自组装与生物膜,纳米材料及技术,药用高分子材料及给药系统 1)可注射温敏原位凝胶材料及其给药系统,以及在抗肿瘤和抗艾滋病粘膜防护中的应用研究;(2)多功能性核酸传递载体及核酸递送系统;(3)经皮给药压敏胶、膜材料和材料对药物经皮渗透的调控作用研究;(4)口服、静脉注射纳米药物的研究

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Xu, S., Wang, W., Li, X., (...), Dong, A., Deng, L, .DocumentSustained release of PTX-incorporated nanoparticles synergized by burst release of DOX·HCl from thermosensitive modified PEG/PCL hydrogel to improve anti-tumor efficiency, European Journal of Pharmaceutical Sciences,2014, 62:267-273 Huang, P., Song, H., Wang, W., (...), Kong, D., Dong, A, .tIntegrin-targeted zwitterionic polymeric nanoparticles with acid-induced disassembly property for enhanced drug accumulation and release in tumor,Biomacromolecules,2014, 15 (8):3128-3138 Lv, Z., Chang, L., Long, X., (...),Deng, L., Dong, A.,Thermosensitive in situ hydrogel based on the hybrid of hyaluronic acid and modified PCL/PEG triblock copolymer, 2014, Carbohydrate Polymers, 108 (1), pp. 26-33 Xiang, Y., Xiao, M., Han, S., (...),Deng, L., Dong, A. Preparation and investigation of high solid content PTX-loaded nanoparticles dispersion via nanoprecipitation method, Journal of Biomaterials Science, Polymer Edition,2014, 25 (11), pp. 1144-1158 Wang, W., Liu, J., Li, C., (...),Dong, A., Kong, D.,Real-time and non-invasive fluorescence tracking of in vivo degradation of the thermosensitive PEGlyated polyester hydrogel,2014, Journal of Materials Chemistry B, 2 (26):4185-4192 Huang, P., Yang, C., Liiu, J., (...),Liu, J., Dong, A.,Improving the oral delivery efficiency of anticancer drugs by chitosan coated polycaprolactone-grafted hyaluronic acid nanoparticles, Journal of Materials Chemistry B, 2014, 2 (25), pp. 4021-4033 Shi, Y., Li, Y., Wu, J., (...), Dong, A., Zhang, J., A novel transdermal drug delivery system based on self-adhesive Janus nanofibrous film with high breathability and monodirectional water-penetration,Journal of Biomaterials Science, Polymer Edition,2014, 25 (7), pp. 713-728 Wang, W., Li, C., Zhang, J., Dong, A., Kong, D.Tailor-made gemcitabine prodrug nanoparticles from well-defined drug-polymer amphiphiles prepared by controlled living radical polymerization for cancer chemotherapy, Journal of Materials Chemistry B,2014, 2 (13), pp. 1891-1901 Zhao, J., Liu, J., Han, S., (...),Dong, A., Zhang, J. Acid-induced disassemblable nanoparticles based on cyclic benzylidene acetal-functionalized graft copolymer via sequential RAFT and ATRP polymerization, Polymer Chemistry,2014,5 (6), pp. 1852-1856 Peng, M., Xu, S., Zhang, Y., (...), Dong, A., Zhang, R., Meng, W. Thermosensitive injectable hydrogel enhances the antitumor effect of embelin in mouse hepatocellular carcinoma, Journal of Pharmaceutical Sciences,2014, 3 (3), pp. 965-973 Wang, W., Zhang, J., Li, C., (...),Dong, A., Kong, D.,Facile access to cytocompatible multicompartment micelles with adjustable Janus-cores from A-block-B-graft-C terpolymers prepared by combination of ROP and ATRP, Colloids and Surfaces B: Biointerfaces,2014, 115, pp. 302-309 Wang, W., Deng, L., Huang, P., (...), Zhang, J., Dong, A. Toxicity and in vivo biological effect of the nanoparticular self-supported hydrogel of a thermosensitive copolymer for non-invasive drug delivery, Journal of Biomedical Materials Research - Part A,2014, 102 (1), pp. 17-29 Han, S., Wan, H., Lin, D., (...),Tang, H., Dong, A. Contribution of hydrophobic/hydrophilic modification on cationic chains of poly(ε-caprolactone)-graft-poly(dimethylamino ethylmethacrylate) amphiphilic co-polymer in gene delivery, Acta Biomaterialia,2014,10 (2), pp. 670-679 Zwitterionic nanoparticles constructed with well-defined reduction-responsive shell and pH-sensitive core for "spatiotemporally Pinpointed" drug delivery,ACS Applied Materials and Interfaces,2014,6 (16), pp. 14631-14643 Zhao, J., Liu, J., Xu, S., (...), Meng, A., Dong*, Graft copolymer nanoparticles with ph and reduction dual-induced disassemblable property for enhanced intracellular curcumin release,ACS Applied Materials and Interfaces, 2013 WD Zhang, Q Cheng, ST Guo, DS Lin, PS Huang, (...),AJ Dong*, Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid, Biomaterials, 34 (27):6495-6503,2013. DS Lin, Q Jiang, Q Cheng, YY Huang, (...),AJ Dong*,Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery, Acta Biomaterialia, 9(8): 7746-7757,2013. DS Lin, Q Cheng, Q Jiang, YY Huang, Z Yang, (...),AJ Dong* Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo, Nanoscale, 5 (10) :4291-4301, 2013. WW Wang, LD Deng, SX Xu, X Zhao,N Lv, (...),AJ Dong*, A reconstituted "two into one" thermosensitive hydrogel system assembled by drug-loaded amphiphilic copolymer nanoparticles for the local delivery of paclitaxel, Journal of Materials Chemistry, B 1 (4): 552-563, 2013. JH Zhang, XN Lin, JF Liu, JQ Zhao, HX Dong, LD Deng,JF Liu, AJ Dong*, Sequential thermo-induced self-gelation and acid-triggered self-release process of drug-conjugated nanoparticles: A strategy for the sustained and controlled drug delivery to tumors, Journal of Materials Chemistry , B 1 (36): 4667-4677 , 2013.

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