个人简介

张欣，女，博士，教授，博士生导师。毕业于吉林大学，2000年获中国科学院长春应用化学研究所硕士，2002年赴法国留学，在斯特拉斯堡第一大学（路易•巴斯德大学，UniversitéLouisPasteur,Strasbourg,France）药学院攻读博士学位，2005年获法国国家博士学位；2006年6月至2008年9月在美国纽约阿尔伯特•爱因斯坦医学院（AlbertEinsteinCollegeofMedicine,NY,USA）分子药理系担任研究助理。2008年底回国，2009年6月起被聘为安徽农业大学生命科学学院讲席教授。在分析化学、天然产物、多肽组学等基础研究领域具有专长，科研能力强。发表SCI论文20多篇，多项研究成果具有重要的科学价值和应用前景，达到本领域国际先进水平。拥有2项国家发明专利。 主要教学经历与成果： 主要研究领域： 1.功能小分子结构及其生理活性的研究：分离制备天然有机功能小分子及其衍生物，研究其化学结构，并运用一系列体内体外模式生物分析相关生理活性，探讨其作用机理。 2.多肽组学研究：开展与植物生理、病理等性状相关的具有生物活性的多肽组学研究。 主要科研项目： 国家自然科学基金项目（21072002）：植物甾醇单体氧化物的制备及其细胞毒性的研究（主持） 教育部留学回国人员科研启动基金（教外司留(2011)1568号）：Δ7-植物甾醇氧化物的合成及生物效应研究（主持）

研究领域

天然产物化学和多肽组学

1.功能小分子结构及其生理活性的研究：分离制备天然有机功能小分子及其衍生物，研究其化学结构，并运用一系列体内体外模式生物分析相关生理活性，探讨其作用机理。 2.多肽组学研究：开展与植物生理、病理等性状相关的具有生物活性的多肽组学研究。

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.LeleZhang,MingleiYang,JunlanGao,ShanJin,ZhengyanWu,LifangWu*,XinZhang*.SeasonalvariationandgenderpatternofphenolicandflavonoidcontensinPistaciachinensisBungeinflorescencesandleaves.JournalofPlantPhysiology2016,191,36-44. 2.JunlanGao,ShaopengChen,LeleZhang,BeijiuCheng,AnXu*,XinZhang*.Evaluationofcytotoxicandapoptoticeffectsofindividualmixed7-ketophytosteroloxidesonhumanintestinalcarcinomacells.JournalofAgriculturalandFoodChemistry2015,63,1035-1041. 3.LuluHe,MinWang,GuilongZhang,GuannanQiu,DongqingCai*,ZhengyanWu*,XinZhang*.RemediationofCr(VI)contaminatedsoilusinglongdurationsodiumthiosulfatesupportedbymicro-nanonetworks.JournalofHazardousMaterials2015,294,64-69. 4.GuilongZhang,RuohongDu,LeleZhang,DongqingCai,XiaoSun,YongZhou,JianZhou,JunchaoQian,KaiZhong,KangZheng,DarnellKaigler,WenqingLiu,XinZhang*,DuohongZou*,ZhengyanWu*.Gadolinium-dopedironoxidenanoprobeadmultifunctionalbioimagingagentanddrugdeliversystem.AdvancedFunctionalMaterials2015,25,6101-6111. 5.LinglinZhou,DongqingCai,LuluHe,NaiqinZhong,MeiYu*,XinZhang*,ZhengyanWu*.Fabricationofahigh-performancefertilizertocontrolthelossofwaterandnutrientusingmicro/nanonetworks.ACSSustainableChemistry&Engineering2015,3,645-653. 6.NaJiang,DongqingCai,LuluHe,NaiqinZhang,HanWen*,XinZhang*,ZhengyanWu*.ACSSustainableChemistry&Engineering2015,3,374-380. 7.QiulinYue,ShiquanXiong,DongqingCai,ZhengyanWu*,XinZhang*.Facileandquantitativeelectrochemicaldetectionofyeastcellapoptosis.ScientificReports2014,4:4373. 8.GuilongZhang,JunlanGao,JunchaoQian,DongqingCai,KangZheng,ZhiwuYu,JunfengWang,KaiZhong*,XinZhang*,ZhengyanWu*.Amultifunctionalmagneticcompositematerialasadrugdeliverysystemandamagneticresonancecontrastagent.Particle&ParticleSystemsCharacterization2014,31,976-984. 9.GuilongZhang,MingleiYang,DongqingCai,KangZheng,XinZhang,LifangWu*,ZhengyanWu*.CompositeoffunctionalmesoporoussilicaandDNA:Anenzyme-responsivecontrolledreleasedrugcarriersystem.ACSAppliedMaterials&Interfaces2014,6,8042-8047. 10.YunfengZong,JunlanGao,HuiyunFeng,BeijiuCheng,XinZhang*.Toxicityof7-ketocholesterolonlethality,growth,reproduction,andgermlineapoptosisinthenematodeCaenorhabditiselegans.JournalofToxicologyandEnvironmentalHealth,PartA2014,77,716-723. 11.ShiquanXiong,JunjieCheng,LuluHe,MinWang,XinZhang*,ZhengyanWu*.Detectionofdi(2-ethylhexyl)phthalatethroughgraphene-β-Cyclodextrincompositesbyelectrochemicalimpedancespectroscopy.AnalyticalMethods2014,6,1736-1742. 12.JunlanGao,QiulinYue,YishunJi,BeijiuCheng,XinZhang*.Novelsynthesisstrategyforpreparationofindividualphytosteroloxides,JournalofAgricuturalandFoodChemistry2013,61,982-988. 13.DongqingCai,LonghaiWang,XinZhang*,ZhengyanWu*.Controllingpesticidelossbynaturalporousmicro/nanocomposites:strawash-basedbiocharandbiosilica.ACSAppliedMaterials&Interfaces2013,5,9212-9216. 14.QiulinYue,XiuhongZhou,QianliLeng,LeleZhang,BeijiuCheng,XinZhang*.7-Ketocholesterol-inducedcaspase-mediatedapoptosisinSaccharomycescerevisiae.FEMSYeastResearch2013,13,796-803. 15.XinZhang,HuiPan,BonniePeng,DonaldF.Steiner,JohnE.Pintar,LloydD.Fricker*.Neuropeptidomicanalysisestablishesamajorroleforprohormoneconvertase-2inneuropeptidebiosynthesis.JournalofNeurochemistry2010,112,1168-1179. 16.DeniseA.Berti,CainMorano,LilianC.Russo,LeandroM.Castro,FernandaM.Cunha,XinZhang,JuanSironi,ClécioF.Klitzke,EmerS.Ferro,LloydD.Fricker*.Analysisofintracellularsubstratesandproductsofthimetoligopeptidase(EC3.4.24.15)inhumanembryonickidney293cells.JournalofBiologicalChemistry2009,284,14105-14116. 17.XinZhang,Fan-YunChe,IrynaBerezniuk,KemalSonmez,LawrenceToll,LloydD.Fricker*.PeptidomicsofCpefat/fatmousebrainregions:Implicationsforneuropeptideprocessing.JournalofNeurochemistry2008,107,1596-1613. 18.CainMorano,XinZhang(co-firstauthor),LloydD.Fricker*.Multipleisotopiclabelsforquantitativemassspectrometry.AnalyticalChemistry2008,80,9298–9309. 19.Fa-yunChe,XinZhang,IrynaBerezniuk,MyrasolCallaway,JihyeonLim,LloydD.Fricker*.Optimizationofneuropeptideextractionfromthemousehypothalamus.JournalofProteomeResearch2007,6,4667-4676. 20.XinZhang,DianeJulien-David,MichelMiesch,FrancisRaul,PhilippeGeoffroy,DalalAoudé-Werner,SaïdEnnahar,EricMarchioni*.Quantitativeanalysisofβ-sitosteroloxidesinvegetableoilsinducedbynaturalsunlight,artificiallygeneratedultravioletlightandirradiation.JournalofAgricuturalandFoodChemistry2006,54,5410-5415. 21.XinZhang,AmandineCambrai,MichelMiesch,StamatikiRoussi,FrancisRaul,DalalAoudé-Werner,EricMarchioni*.Separationof5-and7-phytosterolsbyadsorptionchromatographyandsemi-preparativeRP-HPLCforquantitativeanalysisofphytosterolsinfoods.JournalofAgricuturalandFoodChemistry2006,54,1196-1202. 22.S.Roussi,AWinter,FFosse,DWerner,XZhang,EMarchioni,PGeoffroy,MMiesch,FRaul*.Differentapoptoticmechanismsareinvolvedintheantiproliferativeeffectsof7β-hydroxysitosteroland7β-hydroxycholesterol.CellDeathandDifferentiation2005,12,128-135. 23.XinZhang,DianeJulien-David,MichelMiesch,PhilippeGeoffroy,FrancisRaul,StamatikiRoussi,DalalAoudé-Werner,EricMarchioni*.Identificationandquantitativeanalysisofβ-sitosteroloxidesinvegetableoilsbycapillarygaschromatography-massspectrometry.Steroids2005,70,896-906. 24.XinZhang,PhilippeGeoffroy,MichelMiesch,DianeJulien-David,FrancisRaul,DalalAoudé-Werner,EricMarchioni*.Gram-scalechromatographicpurificationofβ-sitosterol:Synthesisandcharacterizationofβ-sitosteroloxides.Steroids2005,70,886-895.