Tissue adhesives are promising materials for expeditious hemorrhage control, while it remains a grand challenge to engineer a superior formulation with instantaneous adhesion, on‐demand debonding, and the integration of multiple desirable properties such as antibacterial and hemostatic capabilities. Herein, a multifunctional supramolecular tissue adhesive based on guanidinium‐modified polydimethylsiloxane (PDMS) is introduced, driven by a reversible microphase separation mechanism. By optimizing the content of guanidinium ions, precise control over cohesive strength, adhesion, and wettability is achieved, resulting in strong instantaneous adhesion under both dry and wet conditions. Notably, the supramolecular nature of the adhesive allows for convenient on‐demand removal using medical‐grade alcohol, offering a critical advantage for easy debonding. Additionally, the adhesive exhibits remarkable antimicrobial properties while maintaining excellent biocompatibility and hemocompatibility. Its underwater injectability supports minimally invasive surgical procedures. Furthermore, the adhesive's ability to incorporate solid particles enhances its versatility, particularly for the development of drug‐embedded bioadhesives. This work addresses key challenges in tissue adhesive design via a microphase separation‐driven working principle, thereby opening promising new avenues for the development of advanced bioadhesives with tailored properties and enhanced surgical and wound care outcomes.

中文翻译：

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一种具有瞬时干/湿粘合、醇触发脱粘和抗菌止血的微相分离驱动的超分子组织粘合剂

组织粘合剂是快速控制出血的有前途的材料，而设计具有瞬时粘合、按需脱粘以及集成多种理想特性（如抗菌和止血能力）的优质配方仍然是一项巨大的挑战。本文介绍了一种基于胍改性聚二甲基硅氧烷（PDMS）的多功能超分子组织粘合剂，该粘合剂由可逆微相分离机制驱动。通过优化胍离子的含量，实现对内聚强度、附着力和润湿性的精确控制，从而在干湿条件下实现较强的瞬时附着力。值得注意的是，粘合剂的超分子性质允许使用医用级酒精方便地按需去除，为轻松脱粘提供了关键优势。此外，该粘合剂具有卓越的抗菌性能，同时保持出色的生物相容性和血液相容性。其水下注射能力支持微创外科手术。此外，粘合剂掺入固体颗粒的能力增强了其多功能性，特别是对于药物包埋生物粘合剂的开发。这项工作通过微相分离驱动的工作原理解决了组织粘合剂设计中的关键挑战，从而为开发具有定制性能和增强手术和伤口护理结果的先进生物粘合剂开辟了有希望的新途径。