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A dual-response fluorescent probe Rh-O-QL for simultaneous monitoring of NAD(P)H and pH during mitochondrial autophagy
Chemical Communications ( IF 4.2 ) Pub Date : 2025-04-18 , DOI: 10.1039/d5cc00961h
Liandi Guan Wanting Hu Shiyu Zhang Yongjian Ai Qionglin Liang

Mitochondrial autophagy is closely related to abnormal NAD(P)H and pH. Here, we synthesized a dual-response fluorescent probe with high selectivity for NAD(P)H and sensitivity in the physiological pH range, for simultaneous imaging analysis of mitochondrial NAD(P)H and pH, holding potential as a novel tool for understanding mitochondria-associated diseases.

中文翻译:

双反应荧光探针 Rh-O-QL 用于在线粒体自噬过程中同时监测 NAD(P)H 和 pH 值

线粒体自噬与异常的 NAD(P)H 和 pH 值密切相关。在这里,我们合成了一种对 NAD(P)H 具有高选择性和生理 pH 范围内灵敏度的双响应荧光探针,用于线粒体 NAD(P)H 和 pH 值的同时成像分析,具有作为了解线粒体相关疾病的新工具的潜力。
更新日期:2025-04-18
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