The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in managing infectious diseases, this study reviewed the literature on phytotherapy for Mpox, addressing gaps in evidence-based herbal interventions. A thorough search was conducted across the Scopus, PubMed, and Cochrane databases, as well as grey literature, up to August 2024 to retrieve studies on natural compounds with potential efficacy against Mpox and its associated symptoms. Data were analysed for publication characteristics, the compounds or herbal plants investigated, and their effects on the virus. A total of 37 articles with 242 citations were identified, demonstrating a steady increase in research activity since the first study in 2011, peaking in 2023 with 21 publications and 114 citations. The majority of studies originated from Southeast Asian countries. In terms of study design, most investigations were in silico (n = 31, 84%), followed by in vitro studies (n = 4, 11%), with no in vivo or clinical interventions reported. The primary focus was on the antiviral activities of natural products, with polyphenols identified as the most prevalent lead compounds. Whilst these findings highlight the growing interest in phytotherapy for Mpox, they also underscore the predominance of computational studies. To build upon this foundation of in silico evidence, further laboratory and animal studies are imperative for translating these insights into clinical applications. The comprehensive library of compounds gathered through this research provides a valuable resource to facilitate this crucial next step in the development of herbal interventions against Mpox.

中文翻译：

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针对 Mpox 的天然化合物：映射证据和识别差距

猴痘的全球传播需要探索新的治疗方案。考虑到草药在管理传染病方面的既定历史，本研究回顾了 Mpox 植物疗法的文献，解决了循证草药干预中的差距。截至 2024 年 8 月，在 Scopus、PubMed 和 Cochrane 数据库以及灰色文献中进行了彻底检索，以检索对猴痘及其相关症状具有潜在疗效的天然化合物的研究。分析了数据的发表特征、研究的化合物或草药植物及其对病毒的影响。共确定了 37 篇文章，引用 242 次，表明自 2011 年第一次研究以来，研究活动稳步增长，在 2023 年达到顶峰，发表 21 篇出版物，引用 114 次。大多数研究来自东南亚国家。在研究设计方面，大多数研究是计算机模拟 （n = 31， 84%），其次是体外研究 （n = 4， 11%），没有体内或临床干预报告。主要关注点是天然产物的抗病毒活性，其中多酚被确定为最普遍的铅化合物。虽然这些发现凸显了人们对 Mpox 植物疗法日益增长的兴趣，但它们也强调了计算研究的主导地位。为了建立在计算机证据的基础上，进一步的实验室和动物研究对于将这些见解转化为临床应用至关重要。通过这项研究收集的综合化合物库为促进开发针对 Mfox 的草药干预措施的关键下一步提供了宝贵的资源。