Hypertrophic scar (HS) is a plaque fibrous and indurated dermal lesion that may cause physical, psychological, and cosmetic challenges for patients. Intralesional injection of triamcinolone acetonide (TA) is commonly used in clinical practice, which cause unbearable pain and uneven drug delivery within HS tissue. Herein, we developed a paper battery powered iontophoresis-driven microneedles patch (PBIMNP) for self-management of HS. The high integration of PBIMNP was achieved by incorporating a paper battery as the power source for iontophoresis. The transdermal drug delivery strategy of PBIMNP combined microneedles and iontophoresis techniques, involving “pressing and poking, phase transformation, and diffusion and iontophoresis”, which can actively deliver 90.19% drug into the HS tissue with excellent in vitro drug permeation performance. PBIMNP administration effectively reduced the mRNA and protein levels, leading to a decrease in the expression of TGF-β1 and Col I associated with HS formation, demonstrating its efficacy in HS treatment. The microneedles and wearable design endow the PBIMNP as a highly promising platform for self-administration on HS treatment.

增生性疤痕 （HS） 是一种斑块状纤维和硬化的真皮病变，可能会给患者带来身体、心理和美容方面的挑战。病灶内注射曲安奈德 （TA） 在临床实践中常用，可引起难以忍受的疼痛和 HS 组织内药物输送不均匀。在此，我们开发了一种纸电池供电的离子电渗疗法驱动的微针贴片 （PBIMNP），用于 HS 的自我管理。PBIMNP 的高集成度是通过结合纸电池作为离子电渗疗法的电源来实现的。PBIMNP 的透皮给药策略结合了微针和离子电渗疗法技术，涉及“按戳、相变、扩散和离子电渗疗法”，可主动将 90.19% 的药物递送到 HS 组织中，具有优异的体外药物渗透性能。PBIMNP 给药有效降低了 mRNA 和蛋白水平，导致与 HS 形成相关的 TGF-β 1 和 Col I 的表达降低，证明了其在 HS 治疗中的疗效。微针和可穿戴设计使 PBIMNP 成为 HS 治疗自我给药的非常有前途的平台。