One new coumaronochromone named 5,7,2′-trihydroxy-6-methoxycoumaronochromone (1), and six known compounds named benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (2), chikusetsusaponin V (3), crotonine (4), ayamenin A (5), achyranthoside A (6), 5-hydroxypyridine-2-carboxylic acid methyl ester (7), were obtained from Achyranthes bidentata. The antihyperuricemic acid activities of these isolated compounds (1–7) were assayed by an HK-2 cell model induced by adenosine combined with xanthine oxidase. The contents of uric acid produced by the HK-2 cell model were determined by HPLC analysis. As the results show, compound 3 was the most effective and was almost in line with the positive drug of febuxostat, whereas compounds 1, 4, 5, and 6 showed moderate antihyperuricemic acid activities at a concentration of 50.0 μM.

一种名为 5,7,2′-三羟基-6-甲氧基香豆色素酮 （1） 的新型香豆色素酮和六种已知化合物，命名为苄基-O-α-L-鼠李糖吡喃糖基-（1→6）-β-D-吡喃葡萄糖苷 （2）、竹蜡素 V （3）、巴豆宁 （4）、蛋黄素 A （5）、achyranthoside A （6）、5-羟基吡啶-2-羧酸甲酯 （7），是从 Achyranthes bidentata 获得的.通过腺苷结合黄嘌呤氧化酶诱导的 HK-2 细胞模型测定这些分离化合物的抗高尿酸活性 （1-7）。HPLC 分析测定 HK-2 细胞模型产生的尿酸含量。结果表明，化合物 3 是最有效的，几乎与非布司他的阳性药物一致，而化合物 1、4、5 和 6 在浓度为 50.0 μM 时显示出中等的抗高尿酸活性。