Developing a portable yet affordable method for the discrimination of chemical substances with good sensitivity and selectivity is essential for on-site visual detection of unknown substances. Herein, we propose an optofluidic paper-based analytical device (PAD) that consists of a macromolecule-driven flow (MDF) gate and photonic crystal (PhC) coding units, enabling portable and scalable detection and discrimination of various organic chemical, mimicking the olfactory system. The MDF gate is designed for precise flow control of liquid analytes, which depends on intermolecular interactions between the polymer at the MDF gate and the liquid analytes. Subsequently, the PhC coding unit allows for visualizing the result obtained from the MDF gate and generating differential optical patterns. We fabricate an optofluidic PAD by integrating two coding units into a three-dimensional (3D) microfluidic paper within a 3D-printed cartridge. The optofluidic PADs clearly distinguish 11 organic chemicals with digital readout of pattern recognition from colorimetric signals. We believe that our optofluidic coding strategy mimicking the olfactory system opens up a wide range of potential applications in colorimetric monitoring of chemicals observed in environment.

开发一种便携式且经济实惠的化学物质鉴别方法，具有良好的灵敏度和选择性，对于未知物质的现场目视检测至关重要。在此，我们提出了一种基于纸的光流体分析设备 （PAD），它由大分子驱动流动 （MDF） 门和光子晶体 （PhC） 编码单元组成，能够模拟嗅觉系统，实现便携式和可扩展的各种有机化学物质的检测和区分。MDF 闸门设计用于液体分析物的精确流量控制，这取决于 MDF 闸门处的聚合物与液体分析物之间的分子间相互作用。随后，PhC 编码单元允许将从 MDF 门获得的结果可视化并生成差分光学图案。我们通过将两个编码单元集成到 3D 打印墨盒内的三维 （3D） 微流控纸中来制造光流体 PAD。光流体 PAD 通过模式识别的数字读出和比色信号清楚地区分 11 种有机化学物质。我们相信，我们模拟嗅觉系统的光流体编码策略在环境中观察到的化学物质的比色监测中开辟了广泛的潜在应用。