In recent years, the incidence of neurodegenerative diseases, including Alzheimerʼs disease, Parkinsonʼs disease, Huntingtonʼs disease, and amyotrophic lateral sclerosis, has exhibited a steadily rising trend, which has posed a major challenge to the global public health. Traditional Chinese medicine, with its multicomponent and multitarget characteristics, offers a promising approach to treating neurodegenerative diseases. However, comprehensively elucidating the complex mechanisms underlying traditional Chinese medicine formulations remains challenging. As an emerging systems biology method, network pharmacology has provided a vital tool for revealing the multitarget mechanisms of traditional Chinese medicine through high-throughput technologies, molecular docking, and network analysis. This paper reviews the advancements in the application of network pharmacology in treating neurodegenerative diseases using traditional Chinese medicine, analyzes the current status of relevant databases and technological methods, discusses the limitations, and proposes future directions to promote the modernization of traditional Chinese medicine and the development of precision medicine.

中文翻译：

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网络药理学在中医神经退行性疾病治疗中的应用

近年来，阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩侧索硬化症等神经退行性疾病的发病率呈稳步上升趋势，对全球公共卫生构成了重大挑战。中医具有多组分和多靶点的特性，为治疗神经退行性疾病提供了一种很有前途的方法。然而，全面阐明传统中药制剂的复杂机制仍然具有挑战性。网络药理学作为一种新兴的系统生物学方法，通过高通量技术、分子对接和网络分析，为揭示中医的多靶点机制提供了重要工具。本文综述了网络药理学在中医神经退行性疾病中的应用进展，分析了相关数据库和技术方法的现状，讨论了其局限性，并提出了推进中医现代化和精准医学发展的未来方向。